Pezeshki Seyed Mohammad Sadegh, Saki Najmadin, Ghandali Mehran Varnaseri, Ekrami Alireza, Avarvand Arshid Yousefi
Thalassemia & Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.
Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Blood Res. 2021 Mar 31;56(1):38-43. doi: 10.5045/br.2021.2020189.
Immune thrombocytopenia (ITP) is a bleeding disorder. is a Gram-negative bacterium that is presumed to be associated with ITP and therapeutic response of patients. To evaluate the effect of eradication on platelet count of ITP patients, we analyzed the studies conducted on the association between infection and response to therapy in ITP patients in Western Asia focusing on the Middle East region.
A systematic search of databases (PubMed/Medline, ISI Web of Science, Cochrane Central) and Google Scholar search engine results was conducted up until January 2020. The keywords included in the search were and/or , ITP and/or immune thrombocytopenia.
Seven studies comprising a total of 228 patients (193 with successful eradication) were included in this study. The association between eradication and ITP was expressed as odds ratios (OR) and 95% confidence intervals (CI). The findings showed that patients who received eradication treatment for infection had significantly higher OR (OR, 8.83; 95% CI, 2.03‒38.35; =0.004) than those in the non-eradicated group.
Our results indicate a significant therapeutic effect of eradication on the platelet count of patients with chronic ITP. Given the inherent limitations of this study, including the small number of patients, further studies with more patients are recommended.
免疫性血小板减少症（ITP）是一种出血性疾病。[某种细菌名称]是一种革兰氏阴性菌，被认为与ITP及患者的治疗反应有关。为评估根除[该细菌]对ITP患者血小板计数的影响，我们分析了在西亚尤其是中东地区开展的关于[该细菌]感染与ITP患者治疗反应之间关联的研究。
截至2020年1月，对数据库（PubMed/Medline、ISI Web of Science、Cochrane Central）和谷歌学术搜索引擎结果进行了系统检索。检索中使用的关键词包括[该细菌名称]和/或[相关术语]、ITP和/或免疫性血小板减少症。
本研究纳入了7项研究，共228例[该细菌]患者（193例成功根除）。根除[该细菌]与ITP之间的关联以比值比（OR）和95%置信区间（CI）表示。结果显示，接受[该细菌]感染根除治疗的患者的OR显著高于未根除组（OR，8.83；95%CI，2.03‒38.35；P = 0.004）。
我们的结果表明，根除[该细菌]对慢性ITP患者的血小板计数有显著治疗效果。鉴于本研究存在固有局限性，包括患者数量较少，建议开展更多患者参与的进一步研究。
