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肽聚糖结合蛋白（PGBP）修饰的磁性纳米珠用于从血液中分离与脓毒症相关的金黄色葡萄球菌的高效磁捕获

Peptidoglycan binding protein (PGBP)-modified magnetic nanobeads for efficient magnetic capturing of Staphylococcus aureus associated with sepsis in blood.

机构信息

Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea.

Department of Nanobiotechnology, KRIBB School of Biotechnology, University of Science and Technology (UST), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34113, Republic of Korea.

出版信息

Sci Rep. 2019 Jan 15;9(1):129. doi: 10.1038/s41598-018-37194-2.

DOI:10.1038/s41598-018-37194-2
PMID:30644425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6333782/
Abstract

Peptidoglycan-binding protein-modified magnetic nanobeads (PGBP-MNBs) were prepared for efficient magnetic capturing of Staphylococcus aureus (S. aureus), which is associated with sepsis, using the binding affinity of PGBP for the peptidoglycan (PG) layer on S. aureus. These PGBP-MNBs can simply capture S. aureus in plasma within 1 hr or even 15 min. Importantly, they also can capture various types of Gram-positive bacteria, such as Bacillus cereus and methicillin-resistant and methicillin-susceptible S. aureus (MRSA and MSSA). We believe that PGBP-based systems will be used to develop diagnostic systems for Gram-positive bacteria-related diseases.

摘要

肽聚糖结合蛋白修饰的磁性纳米珠（PGBP-MNBs）被制备用于通过肽聚糖结合蛋白（PGBP）与金黄色葡萄球菌（S. aureus）上的肽聚糖（PG）层的结合亲和力来有效捕获与脓毒症相关的金黄色葡萄球菌（S. aureus）。这些 PGBP-MNBs 可以在 1 小时内甚至 15 分钟内简单地从血浆中捕获金黄色葡萄球菌。重要的是，它们还可以捕获各种类型的革兰氏阳性菌，如蜡样芽孢杆菌和耐甲氧西林和甲氧西林敏感的金黄色葡萄球菌（MRSA 和 MSSA）。我们相信基于 PGBP 的系统将被用于开发与革兰氏阳性菌相关疾病相关的诊断系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/d1cb7487c255/41598_2018_37194_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/8394109f3cf5/41598_2018_37194_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/5531e9056899/41598_2018_37194_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/ca292ef6b687/41598_2018_37194_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/4a83c33dba5c/41598_2018_37194_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/d1cb7487c255/41598_2018_37194_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/8394109f3cf5/41598_2018_37194_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/5531e9056899/41598_2018_37194_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/ca292ef6b687/41598_2018_37194_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/4a83c33dba5c/41598_2018_37194_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d29d/6333782/d1cb7487c255/41598_2018_37194_Fig5_HTML.jpg

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