一个由老核孔蛋白和新核孔蛋白组成的嵌合体。

A mosaic of old and young nucleoporins.

机构信息

Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan.

Cell Biology Center and World Research Hub Initiative, Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, Japan

出版信息

J Cell Biol. 2019 Feb 4;218(2):385-386. doi: 10.1083/jcb.201811170. Epub 2019 Jan 15.

DOI:10.1083/jcb.201811170

PMID:30647097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6363444/

Abstract

Some nucleoporins, the nuclear pore complex (NPC) components, have exceptionally long lifetimes. In this issue, Toyama et al. (2019. https://doi.org/10.1083/jcb.201809123) report that NPCs are maintained by a slow piecemeal replacement of NPC components in dividing and terminally differentiated cells and by whole-pore exchange in quiescent cells.

摘要

一些核孔蛋白，核孔复合体（NPC）的组成部分，具有异常长的寿命。在本期杂志中，Toyama 等人（2019 年，https://doi.org/10.1083/jcb.201809123）报告称，NPC 是通过在有丝分裂和终末分化细胞中缓慢地逐个替换 NPC 成分以及在静止细胞中整个孔的交换来维持的。