压力进食：自噬靶向核孔复合物。

Stress eating: Autophagy targets nuclear pore complexes.

机构信息

Max Planck Institute for Biology of Ageing, Cologne, Germany.

Cologne Excellence Cluster for Aging and Age-Associated Diseases, University of Cologne, Cologne, Germany.

出版信息

J Cell Biol. 2020 Jul 6;219(7). doi: 10.1083/jcb.202006007.

DOI:10.1083/jcb.202006007

PMID:32584933

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7337487/

Abstract

Lee et al. (2020. Nat. Cell Biol.https://doi.org/10.1038/s41556-019-0459-2) and, in this issue, Tomioka et al. (2020. J. Cell Biol.https://doi.org/10.1083/jcb.201910063) describe the targeted degradation of nuclear pore complexes (NPCs) by selective autophagy, providing insight into the mechanisms of turnover for individual nucleoporins and entire NPCs.

摘要

李等人（2020. 自然细胞生物学。https://doi.org/10.1038/s41556-019-0459-2）和，在本期中，富冈等人（2020. 细胞生物学杂志。https://doi.org/10.1083/jcb.201910063）描述了核孔复合物（NPCs）通过选择性自噬的靶向降解，为单个核孔蛋白和整个 NPC 的周转机制提供了深入的了解。