Cornish J, Lecamwasam J P, Harrison G, Vanderwee M A, Miller T E
Department of Medicine, University of Auckland, New Zealand.
Br J Exp Pathol. 1988 Dec;69(6):759-70.
The urinary bladder wall is lined by a layer of mucus which is believed to provide an important barrier to bacterial invasion of the urinary tract. Abnormal function of this protective layer could therefore be a factor predisposing the host to urinary tract infection (UTI). This study investigated the contribution of the bladder mucus to host defence in both acute and chronic lower UTI, using a non-obstructive animal model of infection which reproduces many features of the disease in man. The ultrastructural appearance of the infected bladder mucosa was assessed in tissue in which both the layer of mucus and bacterial glycocalyces were stabilized prior to examination by scanning and transmission electron microscopy. The protective role of the mucus layer was determined by disrupting the layer immediately prior to bacterial challenge. Both ultrastructural and bacteriological analyses have shown that infection was increased in those animals where the mucus barrier was disrupted.
膀胱壁内衬一层黏液，据信这层黏液对细菌侵入尿路起到重要的屏障作用。因此，这一保护层的功能异常可能是宿主易患尿路感染（UTI）的一个因素。本研究使用一种非梗阻性感染动物模型，该模型再现了人类疾病的许多特征，调查了膀胱黏液在急性和慢性下尿路感染中对宿主防御的作用。在通过扫描电子显微镜和透射电子显微镜检查之前，对黏液层和细菌糖萼均已稳定的组织中的感染膀胱黏膜的超微结构外观进行了评估。通过在细菌攻击前立即破坏黏液层来确定黏液层的保护作用。超微结构分析和细菌学分析均表明，在黏液屏障被破坏的动物中感染增加。
