1 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Otorhinolaryngology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Am J Rhinol Allergy. 2019 May;33(3):286-293. doi: 10.1177/1945892418824246. Epub 2019 Jan 16.
The roles of Fas in immune system are multifaceted, and the interaction between Fas receptor and Fas ligand is essential for maintaining the immune tolerance. We aimed to assess the level of the expression of Fas receptor on nasal inferior turbinate mucosa in patients with mild persistent allergic rhinitis (M PAR) and moderate to severe (M/S) PAR and determined the relationship between disease severity and production of Fas.
A total of 70 patients with M/S PAR, 70 patients with M PAR, and 70 healthy individuals were enrolled in this study. We obtained biopsies of nasal inferior turbinate mucosa from the participants. The expression of Fas mRNA was evaluated by real-time polymerase chain reaction. The presence and location of Fas were determined by immunohistochemistry. The number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels were measured. Clinical manifestations of patients were assessed by Total Nasal Syndrome Score (TNSS).
The expression of Fas in patients with M/S PAR was decreased significantly compared to the control group and patients with M PAR. Local mucosal expression of Fas was correlated with specific IgE, nasal eosinophil count, and TNSS.
According to the results of this study, there might be a relationship between the expression of Fas receptor on nasal turbinate mucosa and the severity of persistent allergic rhinitis.
Fas 在免疫系统中的作用是多方面的，Fas 受体与 Fas 配体的相互作用对于维持免疫耐受至关重要。本研究旨在评估轻度持续性变应性鼻炎（MPAR）和中重度持续性变应性鼻炎（M/S PAR）患者鼻下鼻甲黏膜中 Fas 受体的表达水平，并确定疾病严重程度与 Fas 产生之间的关系。
本研究纳入了 70 例 M/S PAR 患者、70 例 M PAR 患者和 70 名健康对照者。采集参与者的鼻下鼻甲黏膜活检标本，采用实时聚合酶链反应评估 Fas mRNA 的表达，采用免疫组织化学法检测 Fas 的存在和位置，计数每视野的嗜酸性粒细胞数、血嗜酸性粒细胞计数、总血清 IgE 水平和特异性血清 IgE 水平。采用总鼻症状评分（TNSS）评估患者的临床表现。
与对照组和 M PAR 患者相比，M/S PAR 患者的 Fas 表达显著降低。局部黏膜 Fas 的表达与特异性 IgE、鼻内嗜酸性粒细胞计数和 TNSS 相关。
根据本研究结果，鼻下鼻甲黏膜 Fas 受体的表达可能与持续性变应性鼻炎的严重程度有关。
