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中度/重度持续性变应性鼻炎患者酸性哺乳动物几丁质酶表达与疾病严重程度的相关性

Correlation of acidic mammalian chitinase expression with disease severity in patients with moderate/severe persistent allergic rhinitis.

作者信息

Sadeghi Hamid Reza, Pirayesh Ashkan, Shahsavan Shaghayegh, Amani Soroush, Amini Sayed Asadollah, Samani Keyhan Ghatreh, Deris Fatemeh

机构信息

Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.

Hematopoietic Stem Cell Transplantation and Cell Therapy Research Center, Taleghani Hospital, Shahid Beheshti University of Medical Science, Teheran, Iran.

出版信息

Cent Eur J Immunol. 2020;45(3):294-300. doi: 10.5114/ceji.2020.101251. Epub 2020 Nov 1.

DOI:10.5114/ceji.2020.101251
PMID:33437181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7790003/
Abstract

AIM OF THE STUDY

To assess the level of acidic mammalian chitinase (AMCase) expression and IL-8 in nasal inferior turbinate mucosa in patients with mild and moderate to severe allergic rhinitis (AR).

MATERIAL AND METHODS

Participants in this case-control study were divided into three groups, including patients with moderate and severe persistent allergic rhinitis, cases with mild forms of persistent AR, and control or healthy group. We obtained biopsies of nasal inferior turbinate mucosa from all participants. Expression of AMCase and IL-8 mRNAs were evaluated by real-time polymerase chain reaction (PCR). The serum levels of AMCase and IL-8 were determined by ELISA. The number of eosinophils per field, blood eosinophils, total serum IgE levels, and specific serum IgE levels were measured. Patients' clinical manifestations were assessed by total nasal syndrome score (TNSS).

RESULTS

Expression of AMCase and IL-8 in patients with moderate and severe perineal allergic rhinitis were significantly elevated compared to the control group and patients with mild persistent allergic rhinitis. Serum levels of AMCase and IL-8 were associated with specific IgE, nasal eosinophil count, and TNSS.

CONCLUSIONS

According to the results of this study, there might be a relationship between the expression of AMCase and IL-8 in nasal turbinate mucosa and the severity of allergic rhinitis.

摘要

研究目的

评估轻、中至重度过敏性鼻炎（AR）患者鼻下鼻甲黏膜中酸性哺乳动物几丁质酶（AMCase）的表达水平及白细胞介素-8（IL-8）水平。

材料与方法

本病例对照研究的参与者分为三组，包括中重度持续性过敏性鼻炎患者、轻度持续性AR患者以及对照组或健康组。我们从所有参与者处获取鼻下鼻甲黏膜活检样本。通过实时聚合酶链反应（PCR）评估AMCase和IL-8 mRNA的表达。采用酶联免疫吸附测定法（ELISA）测定血清中AMCase和IL-8的水平。测量每个视野中的嗜酸性粒细胞数量、血液嗜酸性粒细胞、血清总IgE水平和特异性血清IgE水平。通过总鼻综合征评分（TNSS）评估患者的临床表现。

结果

与对照组和轻度持续性过敏性鼻炎患者相比，中重度会阴过敏性鼻炎患者中AMCase和IL-8的表达显著升高。血清中AMCase和IL-8的水平与特异性IgE、鼻嗜酸性粒细胞计数和TNSS相关。

结论

根据本研究结果，鼻下鼻甲黏膜中AMCase和IL-8的表达与过敏性鼻炎的严重程度之间可能存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/b206bd0f57da/CEJI-45-42543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/36a9901f18ef/CEJI-45-42543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/499086a2425e/CEJI-45-42543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/a350ccc05e8e/CEJI-45-42543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/b206bd0f57da/CEJI-45-42543-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/36a9901f18ef/CEJI-45-42543-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/499086a2425e/CEJI-45-42543-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/a350ccc05e8e/CEJI-45-42543-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f6af/7790003/b206bd0f57da/CEJI-45-42543-g004.jpg

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