Department of Biogeosciences, Scientific Research Center, Soran University, Soran, Kurdistan Region, Iraq.
Department of Biology, Faculty of Basic Science, Islamic Azad University, Shahrekord Branch.
Afr Health Sci. 2022 Mar;22(1):630-640. doi: 10.4314/ahs.v22i1.73.
The profile of inflammatory and suppressing cytokines is important to contribute to the disruption of TH1/TH2 balance in Allergic rhinitis (AR).
This study aimed to assess the expression levels of IL-6, IL-18, IL-21, IL-23, and TGF-β in nasal biopsies in AR patients and evaluate its correlation with the severity of AR.
The study included 30 patients with mild persistent allergic rhinitis (MPAR), patients with moderate-to-severe (M/S) PAR, and 30 healthy individuals. The biopsies of nasal inferior turbinate mucosa were collected from each participant. The expression of IL-6, IL-18, IL-21, IL-23, and TGF-β was evaluated by the quantitative real-time polymerase chain reaction. The degree of eosinophil infiltration into the nasal mucosa, blood eosinophils, and total serum IgE level were also measured.
The expression of IL-6, IL-18, and IL-23 in patients with AR significantly increased compared to the control group. Conversely, the gene expression of the TGF-β declined in the M/S PAR group rather than the AR- group. The data did not show a significant difference in the expression of the IL-21 gene between AR+ and AR- groups.
We suggested that inflammatory cytokines including IL-6, IL-18, and IL-23 may be involved in the severity of AR and associated with markers of inflammation.
炎症和抑制性细胞因子的特征对于促成变应性鼻炎（AR）中 TH1/TH2 平衡的破坏很重要。
本研究旨在评估 AR 患者鼻活检中 IL-6、IL-18、IL-21、IL-23 和 TGF-β 的表达水平，并评估其与 AR 严重程度的相关性。
该研究纳入了 30 例轻度持续性变应性鼻炎（MPAR）患者、中重度（M/S）PAR 患者和 30 例健康个体。从每位参与者的下鼻甲鼻黏膜采集活检样本。通过实时定量聚合酶链反应评估 IL-6、IL-18、IL-21、IL-23 和 TGF-β 的表达。还测量了鼻黏膜嗜酸性粒细胞浸润程度、血液嗜酸性粒细胞和总血清 IgE 水平。
与对照组相比，AR 患者的 IL-6、IL-18 和 IL-23 表达显著增加。相反，M/S PAR 组而非 AR+组的 TGF-β 基因表达下降。AR+和 AR-组之间 IL-21 基因的表达无显著差异。
我们认为包括 IL-6、IL-18 和 IL-23 在内的炎症细胞因子可能参与 AR 的严重程度，并与炎症标志物相关。
