Postgraduate Student, Doctorate of Clinical Dentistry (Periodontics), Dental School, University of Western Australia, Nedlands, WA, Australia.
Researcher, Department of Medical, Oral and Biotechnological Sciences, G. D'Annunzio University of Chieti-Pescara, Chieti, Italy.
Implant Dent. 2019 Feb;28(1):74-85. doi: 10.1097/ID.0000000000000854.
The aim of the present study was to review the effectiveness, side effects, and patient acceptance of different concentrations and formulation of chlorhexidine-based mouthwashes used after periodontal and implant surgery.
The PRISMA guideline was adopted in the search strategy using electronic databases PubMed and MEDLINE to identify randomized and case-control prospective studies on humans written in English language and published up to September 2017.
A total of 10 articles were selected for a total of 344 patients. Because of the significant heterogeneity of the outcome measures, meta-analysis was not performed, and the data were summarized in a table. A positive relationship between the use of chlorhexidine and reduction of plaque was found, demonstrating the effectiveness of the substance in terms of antisepsis and decrease of inflammation after periodontal and implant surgery.
Chlorhexidine is recognized as the primary agent for plaque control and the gold standard in preventing infection, although the presence of largely known side effects would affect patient compliance. Future research should be directed at finding chlorhexidine formulation with negligible adverse effects, without compromising or even increasing its effectiveness as the antiseptics and antiplaque agent.
本研究旨在回顾牙周和种植手术后使用不同浓度和配方的基于洗必泰的漱口水的效果、副作用和患者接受度。
采用 PRISMA 指南，检索了 2017 年 9 月之前发表的英文文献的电子数据库 PubMed 和 MEDLINE 中的随机和病例对照前瞻性研究。
共选择了 10 篇文章，共计 344 名患者。由于结局指标存在显著异质性，因此未进行荟萃分析，数据汇总在表格中。使用洗必泰与减少菌斑之间存在正相关关系，表明该物质在牙周和种植手术后具有消毒和减少炎症的功效。
洗必泰被认为是控制菌斑的主要药物，也是预防感染的金标准，尽管存在大量已知的副作用，但会影响患者的依从性。未来的研究应致力于寻找副作用极小的洗必泰配方，同时不降低甚至增加其作为防腐剂和抗菌斑剂的功效。
