PSiTE：一种基于系统发育的肿瘤进化模拟器。
PSiTE: a Phylogeny guided Simulator for Tumor Evolution.
机构信息
Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing, P.R.China.
Human Genetics, Genome Institute of Singapore, A*STAR, Singapore, Singapore.
出版信息
Bioinformatics. 2019 Sep 1;35(17):3148-3150. doi: 10.1093/bioinformatics/btz028.
SUMMARY
Simulating realistic clonal dynamics of tumors is an important topic in cancer genomics. Here, we present Phylogeny guided Simulator for Tumor Evolution, a tool that can simulate different types of tumor samples including single sector, multi-sector bulk tumor as well as single-cell tumor data under a wide range of evolutionary trajectories. Phylogeny guided Simulator for Tumor Evolution provides an efficient tool for understanding clonal evolution of cancer.
AVAILABILITY AND IMPLEMENTATION
PSiTE is implemented in Python and is available at https://github.com/hchyang/PSiTE.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
模拟肿瘤的真实克隆动力学是癌症基因组学中的一个重要课题。在这里，我们提出了 Phylogeny guided Simulator for Tumor Evolution（PSiTE），这是一种可以模拟不同类型肿瘤样本的工具，包括单区域、多区域批量肿瘤以及单细胞肿瘤数据，同时可以在广泛的进化轨迹下进行模拟。Phylogeny guided Simulator for Tumor Evolution 为理解癌症的克隆进化提供了一种有效的工具。
可用性和实现
PSiTE 是用 Python 实现的，可以在 https://github.com/hchyang/PSiTE 上获取。
补充信息
补充数据可在生物信息学在线获得。
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