2 型糖尿病男性退伍军人中是否存在人类免疫缺陷病毒感染的 DNA 甲基化标志物。
DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.
机构信息
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta.
Department Global Health, Emory University Rollins School of Public Health, Atlanta.
出版信息
J Infect Dis. 2019 May 24;219(12):1959-1962. doi: 10.1093/infdis/jiz023.
Abstract
Epigenetic modifications such as DNA methylation are associated with both human immunodeficiency virus (HIV) infection and type 2 diabetes mellitus (T2DM). We investigated epigenetic associations with T2DM according to HIV infection status and assessed interaction effects among 681 male participants of the Veterans Aging Cohort Study. Methylation at previously reported sites, cg1963031 (TXNIP), cg18181703 (SOCS3), and cg09152259 (PROC), was significantly associated with T2DM in HIV-infected individuals. We identified 3 novel associations with suggestive statistical significance: cg1231141 (ADAMTS2), cg19534769 (HGFAC), and cg13163919 (TLE3). Suggestive interaction with HIV infection status was found at cg17862404 (TSC22D1). The implicated genes are involved in inflammation, pancreatic β-cell function, and T2DM pathogenesis.
摘要
表观遗传修饰，如 DNA 甲基化，与人类免疫缺陷病毒 (HIV) 感染和 2 型糖尿病 (T2DM) 都有关联。我们根据 HIV 感染状况，调查了与 T2DM 相关的表观遗传关联，并在 Veterans Aging Cohort Study 的 681 名男性参与者中评估了 681 名男性参与者之间的相互作用效应。在感染 HIV 的个体中，先前报道的 cg1963031 (TXNIP)、cg18181703 (SOCS3) 和 cg09152259 (PROC) 位点的甲基化与 T2DM 显著相关。我们发现了 3 个具有统计学意义的新关联：cg1231141 (ADAMTS2)、cg19534769 (HGFAC) 和 cg13163919 (TLE3)。在 cg17862404 (TSC22D1) 处发现了与 HIV 感染状况的提示性相互作用。所涉及的基因参与炎症、胰腺 β 细胞功能和 T2DM 的发病机制。
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