Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
Center for Applied Biomedical Research (CRBA), Alma Mater Studiorum-University of Bologna, 40138 Bologna, Italy.
Cells. 2019 Jan 15;8(1):55. doi: 10.3390/cells8010055.
Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, 2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and 3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.
核糖体生物发生与癌症之间存在多方面的关系。核糖体生物发生发生在核仁中。阐明涉及核仁功能及其与细胞增殖的关系的机制：1）使人们了解癌细胞中核仁变化的原因及其在肿瘤病理学中的应用，2）确定抑制核糖体生物发生在癌症化疗中的重要性，3）关注核糖体生物发生在癌症发病机制中的改变。这篇综述总结了关于核糖体生物发生与癌症之间这些相关关系的研究里程碑。核仁的结构和功能也将简要描述。
