Han Kewen, Suh Jeewon, Bahl Gaurav
Opt Express. 2018 Nov 26;26(24):31908-31916. doi: 10.1364/OE.26.031908.
High-throughput label-free measurements of the optical and mechanical properties of single microparticles play an important role in biological research, drug development, and related large population assays. However, mechanical detection techniques that rely on the density contrast of a particle with respect to its environment cannot sense neutrally bouyant particles. On the other hand, neutrally buoyant particles may still have a high compressibility contrast with respect to their environment, opening a new window to their detection and analysis. Here we present a label-free high-throughput approach for measuring the compressibility (bulk modulus) of freely flowing microparticles by means of resonant measurements in an opto-mechano-fluidic resonator.
对单个微粒的光学和机械特性进行高通量无标记测量在生物学研究、药物开发及相关大规模检测中发挥着重要作用。然而，依赖于微粒与其环境密度对比的机械检测技术无法检测中性浮力微粒。另一方面，中性浮力微粒相对于其环境仍可能具有高压缩性对比，这为其检测和分析打开了一扇新窗口。在此，我们展示一种无标记高通量方法，通过在光机械流体谐振器中进行谐振测量来测量自由流动微粒的压缩性（体积模量）。
