BACKGROUND: and are the major extended-spectrum -lactamase- (ESBL-) producing organisms increasingly isolated as causes of complicated urinary tract infections and remain an important cause of failure of therapy with cephalosporins and have serious infection control consequence. OBJECTIVE: To assess the prevalence and antibiotics resistance patterns of ESBL-producing and from community-onset urinary tract infections in Jimma University Specialized hospital, Southwest Ethiopia, 2016. METHODOLOGY: A hospital-based cross-sectional study was conducted, and a total of 342 urine samples were cultured on MacConkey agar for the detection of etiologic agents. Double-disk synergy (DDS) methods were used for detection of ESBL-producing strains. A disc of amoxicillin + clavulanic acid (20/10 g) was placed in the center of the Mueller-Hinton agar plate, and cefotaxime (30 g) and ceftazidime (30 g) were placed at a distance of 20 mm (center to center) from the amoxicillin + clavulanic acid disc. Enhanced inhibition zone of any of the cephalosporin discs on the side facing amoxicillin + clavulanic acid was considered as ESBL producer. RESULTS: In the current study, ESBL-producing phenotypes were detected in 23% ( = 17) of urinary isolates, of which accounts for 76.5% ( = 13) and for 23.5% ( = 4). ESBL-producing phenotypes showed high resistance to cefotaxime (100%), ceftriaxone (100%), and ceftazidime (70.6%), while both ESBL-producing and non-ESBL-producing isolates showed low resistance to amikacin (9.5%), and no resistance was seen with imipenem. In the risk factors analysis, previous antibiotic use more than two cycles in the previous year (odds ratio (OR), 6.238; 95% confidence interval (CI), 1.257-30.957; = 0.025) and recurrent UTI more than two cycles in the last 6 months or more than three cycles in the last year (OR, 7.356; 95% CI, 1.429-37.867; = 0.017) were found to be significantly associated with the ESBL-producing groups. CONCLUSION: Extended-spectrum -lactamases- (ESBL-)producing strain was detected in urinary tract isolates. The occurrence of multidrug resistance to the third-generation cephalosporins, aminoglycosides, fluoroquinolones, trimethoprim-sulfamethoxazole, and tetracyclines is more common among ESBL producers. Thus, detecting and reporting of ESBL-producing organisms have paramount importance in the clinical decision-making.