Department of Bioinformatics, Osaka University Graduate School of Medicine, 1-7 Yamadaoka, Suita, Osaka, Japan.
Infection. 2011 Oct;39(5):467-71. doi: 10.1007/s15010-011-0128-2. Epub 2011 Aug 9.
The current increase in the incidence of urinary tract infections (UTIs) worldwide caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli may be due to the high number of ESBL-producing Enterobacteriaceae carriers in the community. However, whether ESBL-producing bacteria can cause UTIs in carriers remains uncertain.
In this study, 21 fecal carriers of ESBL-producing Enterobacteriaceae were assessed for UTIs caused by ESBL-producing E. coli. Bacterial isolates obtained from patients' urine and stool specimens were phenotypically and genotypically examined. Clonal similarities of isolates were assessed by multilocus sequence typing (MLST) and random amplified polymorphic DNA (RAPD) fingerprinting.
The study revealed that 9 of 21 carriers developed UTIs, and genetic analysis showed that 44% of the UTIs developed were caused by the same ESBL-producing E. coli as that found in the feces of the patients.
The ESBL-producing E. coli in carriers can cause UTIs.
目前，世界范围内由产超广谱β-内酰胺酶（ESBL）的大肠杆菌引起的尿路感染（UTI）发病率不断上升，这可能是由于社区中携带产 ESBL 肠杆菌科细菌的数量较高所致。然而，携带产 ESBL 细菌是否会导致携带者发生 UTI 仍不确定。
本研究评估了 21 例产 ESBL 肠杆菌科细菌的粪便携带者是否由产 ESBL 的大肠埃希菌引起 UTI。对从患者尿液和粪便标本中分离出的细菌进行表型和基因型检测。通过多位点序列分型（MLST）和随机扩增 DNA 多态性（RAPD）指纹图谱分析评估分离株的克隆相似性。
研究显示，21 名携带者中有 9 名发生了 UTI，基因分析显示，44%的 UTI 是由与患者粪便中相同的产 ESBL 的大肠埃希菌引起的。
携带者中产 ESBL 的大肠埃希菌可引起 UTI。
