Infectious Diseases Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Eur J Clin Microbiol Infect Dis. 2011 Oct;30(10):1159-62. doi: 10.1007/s10096-011-1202-5. Epub 2011 Mar 12.
The aim of this study was to investigate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing bacteria in patients at various hospital wards and in a group of relatively healthy volunteers, in order to obtain greater knowledge on how common these bacterial strains are in hospital settings and in the general community. Participants (n = 427) were enrolled at a University Hospital and at Primary Health Care Units (PHCUs) in Sweden in 2008 and 2010. The participants provided rectal swabs, which were tested for the occurrence of ESBL-producing bacteria. Positive samples were analysed with polymerase chain reaction (PCR) methods for bacterial strain typing and ESBL phylogroups. In 2008, the prevalence was 2.1% (2/96) in PHCU subjects and 1.8% (2/113) in hospital patients. In 2010, the prevalence was 3.0% (3/100) in PHCU subjects and 6.8% (8/118) in hospital patients. The dominating phylogroups were CTX-M-1 and CTX-M-9. All ESBL-positive isolates were Escherichia coli. We found a higher prevalence of ESBL faecal carriage than expected, both in the hospital setting and in the PHCU group.
本研究旨在调查不同医院病房和一组相对健康的志愿者中，产extended-spectrum beta-lactamase (ESBL)的细菌的流行情况，以便更深入地了解这些细菌在医院环境和普通社区中的普遍程度。参与者（n=427）于 2008 年和 2010 年在瑞典的一所大学医院和基层医疗单位（PHCUs）招募。参与者提供直肠拭子，检测产 ESBL 的细菌。对阳性样本进行聚合酶链反应（PCR）方法分析，以进行细菌株分型和 ESBL phylogroups 分析。2008 年，PHCU 组的流行率为 2.1%（2/96），医院患者为 1.8%（2/113）。2010 年，PHCU 组的流行率为 3.0%（3/100），医院患者为 6.8%（8/118）。主要 phylogroups 为 CTX-M-1 和 CTX-M-9。所有 ESBL 阳性分离株均为大肠杆菌。我们发现，无论是在医院环境还是 PHCU 组，产 ESBL 的粪便携带率都高于预期。
