Winkelmann James A, Eid Aya, Spicer Graham, Almassalha Luay M, Nguyen The-Quyen, Backman Vadim
1Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 USA.
2Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 USA.
Light Sci Appl. 2019 Jan 16;8:7. doi: 10.1038/s41377-018-0117-7. eCollection 2019.
Optical coherence tomography angiography relies on motion for contrast and requires at least two data acquisitions per pointwise scanning location. We present a method termed spectral contrast optical coherence tomography angiography using visible light that relies on the spectral signatures of blood for angiography from a single scan using endogenous contrast. We demonstrate the molecular sensitivity of this method, which enables lymphatic vessel, blood, and tissue discrimination.
光学相干断层扫描血管造影术依靠运动来产生对比度，并且在每个逐点扫描位置至少需要进行两次数据采集。我们提出了一种称为光谱对比光学相干断层扫描血管造影术的方法，该方法使用可见光，依靠血液的光谱特征，通过单次扫描利用内源性对比剂进行血管造影。我们展示了该方法的分子敏感性，它能够区分淋巴管、血液和组织。
