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用单克隆抗体MR-1对豚鼠巨噬细胞进行组织化学鉴定。

Histochemical identification of guinea-pig macrophages by monoclonal antibody MR-1.

作者信息

Kraal G, Shiamatey-Koolma R, Hoffer M, Baker D, Scheper R

机构信息

Department of Cell Biology, Free University, Amsterdam, The Netherlands.

出版信息

Immunology. 1988 Dec;65(4):523-8.

PMID:3065217
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1385560/
Abstract

A monoclonal antibody is described which reacts with monocytes and macrophages of the guinea-pig. The antibody recognizes a cytoplasmic component in the majority of tissue macrophages, as detected by histochemical analysis. It reacts positively with all macrophages in lymphoid organs, including Tingible body macrophages. In addition it recognizes the cells of Von Kupffer in the liver, and macrophages in bone marrow and peritoneal cavity. In comparison to other monoclonal antibodies that have been described in the guinea-pig, MR-1 shows a unique tissue distribution. The antibody is a useful tool to discriminate macrophages by immunohistochemical methods.

摘要

描述了一种与豚鼠单核细胞和巨噬细胞发生反应的单克隆抗体。通过组织化学分析检测，该抗体识别大多数组织巨噬细胞中的一种细胞质成分。它与淋巴器官中的所有巨噬细胞呈阳性反应，包括可染体巨噬细胞。此外，它还识别肝脏中的枯否细胞、骨髓和腹腔中的巨噬细胞。与已报道的豚鼠其他单克隆抗体相比，MR-1显示出独特的组织分布。该抗体是通过免疫组织化学方法鉴别巨噬细胞的有用工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/755c3fa096b3/immunology00152-0032-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/cfe286931f3a/immunology00152-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/1947fc4b9b82/immunology00152-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/ba5e3d9505fd/immunology00152-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/692d4950f6e3/immunology00152-0031-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/71aa7244b5d0/immunology00152-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/755c3fa096b3/immunology00152-0032-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/cfe286931f3a/immunology00152-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/1947fc4b9b82/immunology00152-0030-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/ba5e3d9505fd/immunology00152-0031-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/692d4950f6e3/immunology00152-0031-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/71aa7244b5d0/immunology00152-0032-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3f/1385560/755c3fa096b3/immunology00152-0032-b.jpg

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本文引用的文献

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The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs.通过抗原F4/80免疫组织化学定位确定的小鼠单核吞噬细胞系统。淋巴和造血器官中巨噬细胞、朗格汉斯细胞、网状细胞和树突状细胞之间的关系。
J Exp Med. 1983 Nov 1;158(5):1522-36. doi: 10.1084/jem.158.5.1522.
2
Analysis of cells of the mononuclear phagocyte series in experimental mycobacterial granulomas by monoclonal antibodies.应用单克隆抗体分析实验性分枝杆菌肉芽肿中单核吞噬细胞系列的细胞
Infect Immun. 1983 Jan;39(1):344-52. doi: 10.1128/iai.39.1.344-352.1983.
3
豚鼠作为传染病模型。
Comp Med. 2008 Aug;58(4):324-40.
4
Influence of Mycobacterium bovis BCG vaccination on cellular immune response of guinea pigs challenged with Mycobacterium tuberculosis.牛分枝杆菌卡介苗接种对结核分枝杆菌攻击的豚鼠细胞免疫反应的影响
Clin Vaccine Immunol. 2008 Aug;15(8):1248-58. doi: 10.1128/CVI.00019-08. Epub 2008 May 28.
5
Detection of guinea pig macrophages by a new CD68 monoclonal antibody, PM-1K.
J Mol Histol. 2006 Jan;37(1-2):15-25. doi: 10.1007/s10735-006-9025-x. Epub 2006 May 19.
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Immunology. 1990 Aug;70(4):513-9.
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J Exp Med. 1983 Jul 1;158(1):126-45. doi: 10.1084/jem.158.1.126.
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