头颈部癌症患者的异时性多原发肿瘤的存活率出奇地好。
Survival of patients with head and neck cancer with metachronous multiple primary tumors is surprisingly favorable.
机构信息
Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Department of Radiation Oncology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
出版信息
Head Neck. 2019 Jun;41(6):1648-1655. doi: 10.1002/hed.25595. Epub 2019 Jan 16.
BACKGROUND
The objectives of this study are to determine the incidence and survival rate of patients with head and neck squamous cell carcinoma (HNSCC) with multiple primary tumors (MPT) in the HN-region, lung, or esophagus.
METHODS
Patient and tumor specific data of 1372 patients with HNSCC were collected from both the national cancer registry and patient records to ensure high-quality double-checked data.
RESULTS
The total incidence of MPTs in the HN-region, lung, and esophagus in patients with HNSCC was 11% (149/1372). Patients with lung MPTs and esophageal MPTs had a significant worse 5-year survival than patients with HN-MPTs (29%, 14%, and 67%, respectively, P < 0.001). The 5-year survival rate for synchronous HN MPTs was only 25%, whereas it was surprisingly high for patients with metachronous HN MPT (85%, P < 0.001).
CONCLUSIONS
One of 10 patients with HNSCC develop MPTs in the HN-region, lung, or esophagus. The 5-year survival of patients with metachronous HN MPTs was surprisingly favorable.
背景
本研究旨在确定头颈部鳞状细胞癌（HNSCC）患者中同时患有多原发肿瘤（MPT）于头颈部、肺部或食管的发病率和生存率。
方法
从国家癌症登记处和患者病历中收集了 1372 例 HNSCC 患者的患者和肿瘤特异性数据，以确保高质量的双重核对数据。
结果
HNSCC 患者同时患有头颈部、肺部和食管 MPT 的总发病率为 11%（149/1372）。患有肺部 MPT 和食管 MPT 的患者的 5 年生存率明显低于患有头颈部 MPT 的患者（分别为 29%、14%和 67%，P<0.001）。同步性头颈部 MPT 的 5 年生存率仅为 25%，而同时性头颈部 MPT 的患者的 5 年生存率却出奇地高（85%，P<0.001）。
结论
每 10 例 HNSCC 患者中就有 1 例发生头颈部、肺部或食管 MPT。同时性头颈部 MPT 患者的 5 年生存率出奇地好。
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