Heroiu Cataloiu Adriana-Daniela, Danciu Cezara Elisabeta, Popescu Cristian Radu
Coltea Clinical Hospital, Department of Otorhinolaringology, Bucharest, Romania.
Maedica (Bucur). 2013 Mar;8(1):80-5.
Multiple head and neck cancers are not rare entities and according to studies in the literature, their incidence is increasing. The emergence of multiple cancers is explained by the phenomenon of "field cancerization". Patients with cancer of the upper digestive and respiratory tract develop most often a second malignancy, usually in the upper aero-digestive tract and among them, those with larynx cancer ranks first among patients with multiple cancers. In the literature and in practice, we met rare combination of multiple cancers, associations that appear to be "random", cannot be explained by any of the hypotheses developed: exposure to carcinogens, genetic susceptibility, and immunodeficiency or cancer treatments after index tumor. Follow-up of patients who have had a head and neck cancer and periodic control are important for early detection of multiple cancers.
多发性头颈癌并非罕见疾病,根据文献研究,其发病率正在上升。多发性癌症的出现可由“场癌化”现象来解释。上消化道和呼吸道癌症患者最常发生第二种恶性肿瘤,通常发生在上呼吸道消化道,其中喉癌患者在多发性癌症患者中位居首位。在文献和实践中,我们遇到了罕见的多发性癌症组合,这些组合似乎是“随机”的,无法用已提出的任何假设来解释:接触致癌物、遗传易感性、免疫缺陷或首发肿瘤后的癌症治疗。对头颈癌患者进行随访和定期检查对于早期发现多发性癌症很重要。