Pregnancy-related acquired hemophilia A initially manifesting as pleural hemorrhage: A case report.

RATIONALE

Acquired hemophilia A is a rare hemorrhagic disease in which the body produces specific antibodies that attack factor VIII, resulting in bleeding that is mainly mucocutaneous and associated with soft tissue and the gastrointestinal system. Approximately 50% of this disease derives from basic diseases, such as autoimmune diseases, cancer, and pregnancy.

PATIENT CONCERNS

We report a 35-year-old postpartum female with acquired hemophilia A who initially presented with pleural hemorrhage.

DIAGNOSES

In this patient activated prothrombin time (PT) and activated partial thromboplastin time (APTT) were found, and the factor VIII activity was 12.6%, furthermore Bethesda assay showed a FVIII antibody titer of 7.4 Bethesda units (BUs).

INTERVENTIONS

The treatment requires a 2-pronged approach: treatment of the bleeding and elimination of the inhibitor.

OUTCOMES

After hemostatic agents were used and inhibitors were eradicated, the patient achieved complete remission without relapse.

LESSONS

It is essential to recognize the development of disease earlier in pregnant woman.