Whalen Kristen, Le Nicole K, Laun Jake, Kuykendall Lauren
Department of Plastic Surgery, Morsani College of Medicine, University of South Florida, Tampa, Florida.
Eplasty. 2024 May 3;24:e24. eCollection 2024.
Pyoderma gangrenosum (PG) is a rare disease characterized by ulcerative cutaneous lesions that can occur postoperatively and is often associated with autoimmune disorders. PG is diagnosed by excluding other conditions that can cause ulcerations, such as infections, which may also result in immunosuppressive treatment delays and suboptimal wound care. Operative debridement of wounds has traditionally been avoided in the acute setting secondary to pathergy. This article presents a case of extensive breast PG that was successfully treated with surgical debridement, porcine-derived extracellular matrix, and negative pressure wound therapy while on systemic immunosuppressive therapy.
坏疽性脓皮病（PG）是一种罕见疾病，其特征为术后可出现溃疡性皮肤病变，且常与自身免疫性疾病相关。PG通过排除其他可导致溃疡的病症（如感染）来诊断，感染也可能导致免疫抑制治疗延迟及伤口护理欠佳。由于同形反应，传统上在急性期避免对伤口进行手术清创。本文介绍了一例广泛性乳腺PG病例，该病例在接受全身免疫抑制治疗的同时，通过手术清创、猪源细胞外基质和负压伤口治疗成功治愈。
