Suppr超能文献

非常小的胚胎样干细胞(VSELs)。

Very Small Embryonic-Like Stem Cells (VSELs).

机构信息

From the Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, KY (M.Z.R., J.R., M.K.).

Department of Regenerative Medicine, and Center for Preclinical Research and Technology at Warsaw Medical University, Poland (M.Z.R., M.K.).

出版信息

Circ Res. 2019 Jan 18;124(2):208-210. doi: 10.1161/CIRCRESAHA.118.314287.

Abstract

Results from at least 20 independent laboratories indicate that adult tissues contain rare, early-development stem cells known as very small embryonic-like stem cells (VSELs), which can differentiate into cells from more than one germ layer. Further research on these cells may provide a path forward to application of these cells in regenerative medicine that perhaps may solve several problems inherent in the use of controversial embryonic stem cells (ESCs) and somehow problematic induced pluripotent stem cells (iPSCs).

摘要

至少 20 个独立实验室的结果表明,成人组织中含有罕见的早期发育干细胞,称为非常小的胚胎样干细胞(VSELs),它们可以分化为来自多个胚层的细胞。对这些细胞的进一步研究可能为这些细胞在再生医学中的应用提供一条途径,也许可以解决使用有争议的胚胎干细胞(ESCs)和某些有问题的诱导多能干细胞(iPSCs)所固有的几个问题。

相似文献

1
Very Small Embryonic-Like Stem Cells (VSELs).
Circ Res. 2019 Jan 18;124(2):208-210. doi: 10.1161/CIRCRESAHA.118.314287.
3
VSELs Maintain their Pluripotency and Competence to Differentiate after Enhanced Ex Vivo Expansion.
Stem Cell Rev Rep. 2018 Aug;14(4):510-524. doi: 10.1007/s12015-018-9821-1.
4
Endogenous lung stem cells: what is their potential for use in regenerative medicine?
Expert Rev Respir Med. 2010 Jun;4(3):349-62. doi: 10.1586/ers.10.21.
5
Very small embryonic-like stem cells for regenerative medicine: WO2010039241.
Expert Opin Ther Pat. 2010 Aug;20(8):1103-6. doi: 10.1517/13543776.2010.495122.
6
Endogenous, very small embryonic-like stem cells: critical review, therapeutic potential and a look ahead.
Hum Reprod Update. 2016 Dec;23(1):41-76. doi: 10.1093/humupd/dmw030. Epub 2016 Sep 10.
7
Adult stem cells as an alternative source of multipotential (pluripotential) cells in regenerative medicine.
Curr Stem Cell Res Ther. 2009 May;4(2):107-17. doi: 10.2174/157488809788167427.
8
Mesenchymal Stem Cells Derived from Human Adipose Tissue.
Methods Mol Biol. 2015;1340:53-64. doi: 10.1007/978-1-4939-2938-2_4.
9
A dive into the stem cells world.
Panminerva Med. 2009 Mar;51(1):1-3.
10
How to mend a broken heart: adult and induced pluripotent stem cell therapy for heart repair and regeneration.
Drug Discov Today. 2015 Jun;20(6):667-85. doi: 10.1016/j.drudis.2015.02.010. Epub 2015 Feb 23.

引用本文的文献

2
Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine.
Front Bioeng Biotechnol. 2025 Mar 7;13:1564964. doi: 10.3389/fbioe.2025.1564964. eCollection 2025.
4
models of leukemia development: the role of very small leukemic stem-like cells in the cellular transformation cascade.
Front Cell Dev Biol. 2025 Jan 3;12:1463807. doi: 10.3389/fcell.2024.1463807. eCollection 2024.
6
Selected stem cell populations in pediatric acute lymphoblastic leukemia.
Front Immunol. 2024 Sep 25;15:1446687. doi: 10.3389/fimmu.2024.1446687. eCollection 2024.
7
How Stem and Progenitor Cells Can Affect Renal Diseases.
Cells. 2024 Aug 30;13(17):1460. doi: 10.3390/cells13171460.
8
Progesterone receptor is constitutively expressed in induced Pluripotent Stem Cells (iPSCs).
Stem Cell Rev Rep. 2024 Nov;20(8):2303-2317. doi: 10.1007/s12015-024-10776-6. Epub 2024 Aug 22.
9
The Phoenix of stem cells: pluripotent cells in adult tissues and peripheral blood.
Front Bioeng Biotechnol. 2024 Jul 30;12:1414156. doi: 10.3389/fbioe.2024.1414156. eCollection 2024.
10
Cancer Represents Dysfunctions of Stem Cells Rather than Misbehavior of Differentiated Cells.
Stem Cell Rev Rep. 2024 Oct;20(7):1995-1997. doi: 10.1007/s12015-024-10766-8. Epub 2024 Jul 30.

本文引用的文献

1
Will iPS Cells Regenerate or Just Provide Trophic Support to the Diseased Tissues?
Stem Cell Rev Rep. 2018 Oct;14(5):629-631. doi: 10.1007/s12015-018-9837-6.
3
VSELs Maintain their Pluripotency and Competence to Differentiate after Enhanced Ex Vivo Expansion.
Stem Cell Rev Rep. 2018 Aug;14(4):510-524. doi: 10.1007/s12015-018-9821-1.
4
Pluripotent Stem Cells in Adult Tissues: Struggling To Be Acknowledged Over Two Decades.
Stem Cell Rev Rep. 2017 Dec;13(6):713-724. doi: 10.1007/s12015-017-9756-y.
5
Why are hematopoietic stem cells so 'sexy'? on a search for developmental explanation.
Leukemia. 2017 Aug;31(8):1671-1677. doi: 10.1038/leu.2017.148. Epub 2017 May 15.
7
Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l.
Cell Rep. 2017 Feb 21;18(8):1930-1945. doi: 10.1016/j.celrep.2017.01.074.
9
Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications.
Stem Cell Rev Rep. 2017 Feb;13(1):7-16. doi: 10.1007/s12015-016-9680-6.
10
Molecular Obstacles to Clinical Translation of iPSCs.
Cell Stem Cell. 2016 Sep 1;19(3):298-309. doi: 10.1016/j.stem.2016.06.017. Epub 2016 Jul 21.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验