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融合结合蛋白 1（FUBP1）的表达受 T 细胞急性淋巴细胞白血病蛋白 1（TAL1）上调，并且是红细胞分化所必需的。

FUSE binding protein 1 (FUBP1) expression is upregulated by T-cell acute lymphocytic leukemia protein 1 (TAL1) and required for efficient erythroid differentiation.

机构信息

Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy, Frankfurt/Main, Germany.

Institute for Transfusion Medicine and Immunohematology, Goethe-University and German Red Cross Blood Service, Frankfurt am Main, Germany.

出版信息

PLoS One. 2019 Jan 17;14(1):e0210515. doi: 10.1371/journal.pone.0210515. eCollection 2019.

DOI:10.1371/journal.pone.0210515
PMID:30653565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6336336/
Abstract

During erythropoiesis, haematopoietic stem cells (HSCs) differentiate in successive steps of commitment and specification to mature erythrocytes. This differentiation process is controlled by transcription factors that establish stage- and cell type-specific gene expression. In this study, we demonstrate that FUSE binding protein 1 (FUBP1), a transcriptional regulator important for HSC self-renewal and survival, is regulated by T-cell acute lymphocytic leukaemia 1 (TAL1) in erythroid progenitor cells. TAL1 directly activates the FUBP1 promoter, leading to increased FUBP1 expression during erythroid differentiation. The binding of TAL1 to the FUBP1 promoter is highly dependent on an intact GATA sequence in a combined E-box/GATA motif. We found that FUBP1 expression is required for efficient erythropoiesis, as FUBP1-deficient progenitor cells were limited in their potential of erythroid differentiation. Thus, the finding of an interconnection between GATA1/TAL1 and FUBP1 reveals a molecular mechanism that is part of the switch from progenitor- to erythrocyte-specific gene expression. In summary, we identified a TAL1/FUBP1 transcriptional relationship, whose physiological function in haematopoiesis is connected to proper erythropoiesis.

摘要

在红细胞生成过程中，造血干细胞（HSCs）通过连续的定向和特化步骤分化为成熟的红细胞。这个分化过程受到转录因子的控制，这些转录因子建立了阶段和细胞类型特异性的基因表达。在这项研究中，我们证明了 FUSE 结合蛋白 1（FUBP1），一种对 HSC 自我更新和存活很重要的转录调节剂，在红系祖细胞中受到 T 细胞急性淋巴细胞白血病 1（TAL1）的调控。TAL1 直接激活 FUBP1 启动子，导致红系分化过程中 FUBP1 表达增加。TAL1 与 FUBP1 启动子的结合高度依赖于 E 盒/GATA 基序中完整的 GATA 序列。我们发现 FUBP1 的表达对于有效的红细胞生成是必需的，因为 FUBP1 缺陷的祖细胞在其红细胞分化的潜力上受到限制。因此，发现 GATA1/TAL1 和 FUBP1 之间的相互联系揭示了一个分子机制，该机制是从祖细胞到红细胞特异性基因表达转变的一部分。总之，我们鉴定了 TAL1/FUBP1 的转录关系，其在造血中的生理功能与正常的红细胞生成有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/d5840c0697b1/pone.0210515.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/2435615eb97b/pone.0210515.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/f1015c251b76/pone.0210515.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/90e789ba14b8/pone.0210515.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/0311d62085fa/pone.0210515.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/55dee6f664db/pone.0210515.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/d5840c0697b1/pone.0210515.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/2435615eb97b/pone.0210515.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/f1015c251b76/pone.0210515.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/90e789ba14b8/pone.0210515.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/0311d62085fa/pone.0210515.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/55dee6f664db/pone.0210515.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/aa4a/6336336/d5840c0697b1/pone.0210515.g006.jpg

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2
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Nature. 2018 Mar 1;555(7694):54-60. doi: 10.1038/nature25741. Epub 2018 Feb 21.
3
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Bioengineered. 2022 May;13(5):12115-12126. doi: 10.1080/21655979.2022.2073115.
4
The transcription factor TAL1 and miR-17-92 create a regulatory loop in hematopoiesis.转录因子 TAL1 和 miR-17-92 在造血过程中形成一个调节环。
Sci Rep. 2020 Dec 8;10(1):21438. doi: 10.1038/s41598-020-78629-z.
5
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Int J Oncol. 2020 Aug;57(2):488-499. doi: 10.3892/ijo.2020.5080. Epub 2020 Jun 10.
6
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Cell Death Dis. 2020 Jun 18;11(6):473. doi: 10.1038/s41419-020-2674-y.
Nature. 2018 Jan 11;553(7687):212-216. doi: 10.1038/nature25168. Epub 2018 Jan 3.
4
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