Scientific Consultant Assited Reproductive Technology, Laboratoire Clement, Paris, France.
Scientific Consultant Assited Reproductive Technology, London Fertility Associates, London, UK.
Mol Reprod Dev. 2019 Oct;86(10):1273-1282. doi: 10.1002/mrd.23116. Epub 2019 Feb 7.
Life expectancy has increased since World War II, and this may be attributed to several aspects of modern lifestyles. However, now we are faced with a downturn, which seems to be the result of environmental issues. This paradigm is paralleled with reduced human fertility, decreased sperm quality, increased premature ovarian failure, and diminished ovarian reserve syndromes. Endocrine disruptor chemicals and other toxic chemicals, herbicides, pesticides, plasticizers, to mention a few, are a rising concern in today's environment. Some of these are commonly used in the domestic setting: cleaning material and cosmetics and they have a known impact on epigenesis and imprinting via perturbation of methylation processes. Pollution from polyaromatic hydrocarbons, particulate matter <10 and <2.5 μm, and ozone released into the air, all affect fertility. Poor food processing management is a source of DNA adduct formation, which impairs the quality of gametes. An important concern is the nanoparticles that are present in food and are thought to induce oxidative stress. Now is the time to take a step backward. Global management of the environment and food production is required urgently to protect the fertility of future generations.
自二战以来，人类的预期寿命有所增加，这可能归因于现代生活方式的几个方面。然而，现在我们正面临着一个衰退期，这似乎是环境问题造成的。这种模式与人类生育率下降、精子质量下降、卵巢早衰增加和卵巢储备综合征减少有关。内分泌干扰化学物质和其他有毒化学物质、除草剂、杀虫剂、增塑剂等，是当今环境中令人担忧的一个问题。其中一些在家庭环境中很常见：清洁材料、化妆品，它们通过干扰甲基化过程，对表观遗传和印迹产生已知的影响。多环芳烃、<10μm 和 <2.5μm 的颗粒物以及臭氧释放到空气中造成的污染，都对生育能力有影响。不良的食物加工管理是 DNA 加合物形成的一个来源，它会损害配子的质量。一个令人关注的问题是存在于食物中的纳米颗粒，它们被认为会引起氧化应激。现在是时候后退一步了。迫切需要对环境和食物生产进行全球管理，以保护子孙后代的生育能力。
