Research &Development Center, China Tobacco Yunnan Industrial Co., Ltd, Kunming 650201, China.
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
Fitoterapia. 2019 Mar;133:146-149. doi: 10.1016/j.fitote.2019.01.006. Epub 2019 Jan 14.
Three new hopane-type triterpenoids (1-3), fern-7(8)-en-19α, 28-diol (1), pteron-14-ene-7α,19α,28-triol (2) and 3β,4α,25-trihydroxyfilican (3), were isolated from the aerial parts of Adiantum capillus-veneris. Their structures were determined by NMR spectroscopic and mass spectrometric data. Compounds 2 and 3 exhibited remarkable antifungal activity against Helminthosporium maydis and Alternaria alternata with MIC values of 12.5-3.125 μg/mL, and compound 3 also against Verticillium dahliae Kleb with an MIC value of 3.125 μg/mL. In addition, compounds 1-3 also displayed weak antibacterial activity against Micrococcus lysodeikticus, Bacterium paratyphosum B and Pseudomonas aeruginosa with an MIC value of 100 μg/mL.
从凤尾蕨的地上部分分离得到三个新的藿烷型三萜（1-3）：蕨-7(8)-烯-19α,28-二醇（1）、翼籽-14-烯-7α,19α,28-三醇（2）和 3β,4α,25-三羟基菲立烯（3）。它们的结构通过 NMR 光谱和质谱数据确定。化合物 2 和 3 对玉米大斑病菌和链格孢菌表现出显著的抗真菌活性，MIC 值为 12.5-3.125μg/mL，化合物 3 对茄病镰刀菌也表现出抗真菌活性，MIC 值为 3.125μg/mL。此外，化合物 1-3 对微球菌溶壁亚种、副伤寒杆菌 B 和铜绿假单胞菌也表现出较弱的抗菌活性，MIC 值为 100μg/mL。
