Odak Jenipher Akinyi, Manguro Lawrence Onyango Arot, Wong Keng-Chong
a Chemistry Department , Maseno University , Maseno 40105 , Kenya.
b School of Chemical Sciences , Universiti Sains Malaysia , Penang 11800 , Malaysia.
J Asian Nat Prod Res. 2018 Jun;20(6):510-524. doi: 10.1080/10286020.2017.1420648. Epub 2018 Jan 17.
The plant species Elaeodendron buchananii Loes is widely used in folklore medicine to manage microbial infections in Kenya. Previous studies on the plant fruits and root bark revealed the presence of steroids and terpenoids. The present phytochemical analysis of the plant stem bark has led to the isolation of four new triterpenes characterized as methyl 3β-acetoxy-11α, 19α, 28-trihydroxyurs-12-en-23-oic acid (1), 3β, 11α, 19α-trihydroxyurs-12-en-23, 28-dioic acid (2), 3β-acetoxy-19α, 23, 28-trihydroxyurs-12-ene (3) and 3-oxo-19α, 28-dihydroxyurs-12-en-24-oic acid (4), together with ten known ones (5-14), whose structures were elucidated using spectroscopic techniques. The isolate canophyllol (8) showed promising antibacterial activity against N. meningitides with MIC value of 31.25 μg/ml.
布氏 Elaeodendron buchananii Loes 植物物种在肯尼亚民间医学中被广泛用于治疗微生物感染。先前对该植物果实和根皮的研究表明其中存在类固醇和萜类化合物。目前对该植物茎皮的植物化学分析已导致分离出四种新的三萜类化合物，其特征为 3β - 乙酰氧基 - 11α, 19α, 28 - 三羟基乌苏 - 12 - 烯 - 23 - 酸（1）、3β, 11α, 19α - 三羟基乌苏 - 12 - 烯 - 23, 28 - 二酸（2）、3β - 乙酰氧基 - 19α, 23, 28 - 三羟基乌苏 - 12 - 烯（3）和 3 - 氧代 - 19α, 28 - 二羟基乌苏 - 12 - 烯 - 24 - 酸（4），以及十种已知化合物（5 - 14），其结构通过光谱技术得以阐明。分离出的卡诺菲醇（8）对脑膜炎奈瑟菌显示出有前景的抗菌活性，MIC 值为 31.25 μg/ml。
