School of Public Health, Capital Medical University, Beijing 100069, China.
Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.
Exp Gerontol. 2019 Apr;118:72-77. doi: 10.1016/j.exger.2019.01.010. Epub 2019 Jan 14.
The association between superoxide dismutase (SOD) activity and cognitive decline in older adults remains controversial.
This study was designed to examine the association between plasma superoxide dismutase (SOD) activity and cognitive decline in older population.
We analyzed the follow-up data from 2012 to 2014 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS), a community-based longitudinal survey in Chinese longevity areas. A total of 1004 Chinese adults aged 60 years and older were included in this study. Plasma SOD activity was assessed. Cognitive function was evaluated by Mini-Mental State Examination (MMSE) in Chinese version. Modified Poisson regression was performed to investigate the association between plasma SOD activities with cognitive decline. Restricted cubic spline was performed to determine the dose-response relationship.
Participants in the highest quartile of SOD activity had an increased risk of cognitive decline compared with those in the lowest quartile (relative risk [RR] = 1.32, 95% confidence interval [CI]: 1.00-1.74, P = 0.051).Using cut-off points determined by Chi-square automatic interaction detector analysis (CHAID), the multivariable relative risks (RRs; 95% CI) for the lowest category, second highest, and the highest versus the third highest category of SOD activity were 0.56 (0.34-0.92), 1.26 (1.03-1.54), and 0.96 (0.70-1.31), respectively.
Higher SOD activity was associated with elevated risk of cognitive decline among Chinese older adults.
超氧化物歧化酶 (SOD) 活性与老年人认知能力下降之间的关系仍存在争议。
本研究旨在探讨老年人群血浆超氧化物歧化酶 (SOD) 活性与认知能力下降之间的关系。
我们分析了中国长寿地区社区为基础的纵向研究——中国长寿纵向研究（CLHLS）2012 年至 2014 年随访数据。共纳入 1004 名年龄在 60 岁及以上的中国成年人。评估血浆 SOD 活性。认知功能采用中文版简易精神状态检查（MMSE）进行评估。采用修正泊松回归分析评估血浆 SOD 活性与认知能力下降之间的关系。采用受限立方样条确定剂量-反应关系。
与 SOD 活性最低四分位数的参与者相比，SOD 活性最高四分位数的参与者认知能力下降的风险增加（相对风险 [RR] = 1.32，95%置信区间 [CI]：1.00-1.74，P = 0.051）。使用卡方自动交互检测分析（CHAID）确定的截断点，SOD 活性最低、第二高和最高三分位数与第三高三分位数相比，多变量相对风险（RR；95%CI）分别为 0.56（0.34-0.92）、1.26（1.03-1.54）和 0.96（0.70-1.31）。
较高的 SOD 活性与中国老年人认知能力下降风险增加相关。
