Webel Allison R, Schreiner Nathaniel, Salata Robert A, Friedman Jared, Jack Anthony I, Sattar Abdus, Fresco David M, Rodriguez Margaret, Moore Shirley
1 Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
2 University Hospitals Harrington Heart & Vascular Institute, Cleveland, OH, USA.
West J Nurs Res. 2019 Jul;41(7):990-1008. doi: 10.1177/0193945918823347. Epub 2019 Jan 17.
People living with HIV (PLHIV) are increasingly diagnosed with comorbidities which require increasing self-management. We examined the effect of a self-management intervention on neurocognitive behavioral processing. Twenty-nine PLHIV completed a two-group, 3-month randomized clinical trial testing a self-management intervention to improve physical activity and dietary intake. At baseline and 3 months later, everyone completed validated assessments of physical, diet, and neurocognitive processing (functional magnetic resonance imaging [fMRI]-derived network analyses). We used linear mixed effects modeling with a random intercept to examine the effect of the intervention. The intervention improved healthy eating ( = .08) but did not improve other self-management behaviors. There was a significant effect of the intervention on several aspects of neurocognitive processing including in the task positive network (TPN) differentiation ( = .047) and an increase in the default mode network (DMN) differentiation ( = .10). Self-management interventions may influence neurocognitive processing in PLHIV, but those changes were not associated with positive changes in self-management behavior.
感染艾滋病毒的人（PLHIV）越来越多地被诊断出患有需要加强自我管理的合并症。我们研究了自我管理干预对神经认知行为处理的影响。29名PLHIV完成了一项为期3个月的两组随机临床试验，测试一种自我管理干预措施，以改善身体活动和饮食摄入。在基线和3个月后，每个人都完成了对身体、饮食和神经认知处理的有效评估（功能磁共振成像[fMRI]衍生的网络分析）。我们使用具有随机截距的线性混合效应模型来研究干预的效果。干预改善了健康饮食（P = 0.08），但没有改善其他自我管理行为。干预对神经认知处理的几个方面有显著影响，包括任务积极网络（TPN）分化（P = 0.047）以及默认模式网络（DMN）分化增加（P = 0.10）。自我管理干预可能会影响PLHIV的神经认知处理，但这些变化与自我管理行为的积极变化无关。
