Liu Tianji, Zhang Wenqi, Xiao Shuai, Xu Lei, Wen Qiang, Bai Lin, Ma Qingjie, Ji Bin
Department of Nuclear Medicine, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China,
Department of Nursing, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Cancer Manag Res. 2019 Jan 4;11:467-474. doi: 10.2147/CMAR.S183299. eCollection 2019.
The aim of this study was to evaluate the efficacy of mindfulness-based stress reduction (MBSR) on health-related quality of life (QoL), depression, and anxiety in patients with differentiated thyroid cancer (DTC) receiving radioactive iodine therapy (RIT).
A randomized controlled trial of MBSR with 120 DTC patients was performed. They were randomly assigned into the MBSR intervention group and usual care (UC) group. An 8-week MBSR program was administered to the MBSR group starting 8 weeks before RIT. Health-related QoL, depression, and anxiety were measured immediately before the start of MBSR (T1), immediately after RIT hospitalization was concluded (1 week after concluding the last MBSR session, T2), and 3 months after RIT hospitalization (T3), using the QoL Questionnaire Core 30 Items (QLQ-C30), Self-rating Depression Scale (SDS), and Self-rating Anxiety Scale (SAS).
Fifty-three patients in the UC group and 49 patients in the MBSR group completed the study and were analyzed. Both the UC and MBSR groups reported low QoL and high SDS and SAS scores immediately after RIT hospitalization. Patients randomly assigned to the MBSR group showed significantly greater improvements in emotional function (=0.012, =-0.03 for T2 and =1.17 for T3), fatigue (=0.037, =1.00 for T2 and =-0.69 for T3), global QoL (=0.015, =1.61 for T2 and =1.56 for T3), depression (=0.027, =-1.19 for T2 and =-0.83 for T3), and anxiety (=0.043, =-1.00 for T2 and =-0.86 for T3).
An 8-week MBSR program significantly improved a wide range of scales in health-related QoL and mitigated depression and anxiety among DTC patients receiving RIT.
本研究旨在评估基于正念减压疗法（MBSR）对接受放射性碘治疗（RIT）的分化型甲状腺癌（DTC）患者的健康相关生活质量（QoL）、抑郁和焦虑的疗效。
对120例DTC患者进行了MBSR随机对照试验。他们被随机分为MBSR干预组和常规护理（UC）组。MBSR组在RIT前8周开始接受为期8周的MBSR项目。使用生活质量问卷核心30项（QLQ-C30）、自评抑郁量表（SDS）和自评焦虑量表（SAS），在MBSR开始前（T1）、RIT住院结束后立即（最后一次MBSR课程结束后1周，T2）以及RIT住院后3个月（T3）测量健康相关QoL、抑郁和焦虑。
UC组53例患者和MBSR组49例患者完成了研究并进行了分析。UC组和MBSR组在RIT住院后立即报告生活质量较低，SDS和SAS评分较高。随机分配到MBSR组的患者在情感功能（T2时P = 0.012，差异=-0.03；T3时差异=1.17）、疲劳（T2时P = 0.037，差异=1.00；T3时差异=-0.69）、总体生活质量（T2时P = 0.015，差异=1.61；T3时差异=1.56）、抑郁（T2时P = 0.027，差异=-1.19；T3时差异=-0.83）和焦虑（T2时P = 0.043，差异=-1.00；T3时差异=-0.86）方面有显著更大的改善。
为期8周的MBSR项目显著改善了接受RIT的DTC患者健康相关生活质量的广泛指标，并减轻了抑郁和焦虑。
