布氏冈比亚锥虫不同发育阶段的多克隆B细胞刺激和免疫抑制活性

Polyclonal B-cell stimulative and immunosuppressive activities at different developmental stages of Trypanosoma gambiense.

作者信息

Oka M, Yabu Y, Ito Y, Takayanagi T

机构信息

Department of Parasitology, School of Medicine, University of Tokushima.

出版信息

Microbiol Immunol. 1988;32(11):1175-7. doi: 10.1111/j.1348-0421.1988.tb01481.x.

DOI:10.1111/j.1348-0421.1988.tb01481.x

PMID:3065588

Abstract

Bloodstream trypomastigote and cultured procyclic (insect midgut) forms of a monomophic strain of Trypanosoma gambiense were tested for their abilities to induce polyclonal B-cell activation (PBA) and immunosuppression (IS) in mice. Injection of a cell homogenate of bloodstream trypomastigotes induced both PBA and IS, while neither PBA nor IS was observed in mice injected with a cell homogenate of cultured procyclics. The results indicate that the substance(s) inducing PBA or IS is related to the developmental stage of the parasites.

摘要

对布氏冈比亚锥虫单型株的血流型锥鞭毛体和培养的前循环型（昆虫中肠）形态进行了测试，以检测它们在小鼠中诱导多克隆B细胞激活（PBA）和免疫抑制（IS）的能力。注射血流型锥鞭毛体的细胞匀浆可诱导PBA和IS，而注射培养的前循环型细胞匀浆的小鼠中未观察到PBA或IS。结果表明，诱导PBA或IS的物质与寄生虫的发育阶段有关。