Song Sang-Hyuk, Jee Yong-Seok, Ko Il-Gyu, Lee Sang-Won, Sim Young-Je, Kim Dae-Young, Lee Sam-Jun, Cho Young Sam
Department of Physical Activity Design, Hanseo University, Seosan, Korea.
Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea.
J Exerc Rehabil. 2018 Dec 27;14(6):911-919. doi: 10.12965/jer.1836508.254. eCollection 2018 Dec.
Brain inflammation is involved in many brain disorders, such as brain ischemic injury, Alzheimer diseases, and Parkinson disease. Physical exercise has been recommended for the prevention and treatment of many brain inflammatory diseases. In the present study, the effects of exercise on motor function in relation with apoptotic neuronal cell death following neuroinflammation were investigated. Moreover, we compared the effect of forced exercise with voluntary exercise on neuroinflammation-induced motor malfunction. For this study, rota-rod test, vertical pole test, foot fault test, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemistry for caspase-3, and western blot for Bcl-2 and Bax were performed. Lipopolysaccharide was intraventricular infused for induction of brain inflammation. Treadmill exercise and wheel exercise were conducted during 6 weeks. In the present results, Treadmill exercise and wheel exercise alleviated brain inflammation-induced motor impairments by suppressing apoptotic neuronal cell death in the motor cortex. These effects of treadmill exercise and wheel exercise were similarly appeared.
脑炎症与许多脑部疾病有关，如脑缺血损伤、阿尔茨海默病和帕金森病。体育锻炼已被推荐用于预防和治疗多种脑部炎症性疾病。在本研究中，研究了运动对神经炎症后与凋亡性神经元细胞死亡相关的运动功能的影响。此外，我们比较了强迫运动和自愿运动对神经炎症诱导的运动功能障碍的影响。对于本研究，进行了转棒试验、垂直杆试验、足部失误试验、末端脱氧核苷酸转移酶介导的dUTP缺口末端标记（TUNEL）分析、半胱天冬酶-3免疫组织化学以及Bcl-2和Bax的蛋白质印迹分析。通过脑室内注入脂多糖来诱导脑部炎症。在6周内进行跑步机运动和轮转运动。在目前的结果中，跑步机运动和轮转运动通过抑制运动皮层中凋亡性神经元细胞死亡减轻了脑炎症诱导的运动障碍。跑步机运动和轮转运动的这些效果相似。
