Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, PR China; Zhejiang Huahai Pharmaceutical Co. LTD., Chuan Nan Site No. 1 Branch Factory, Duqiao, Linhai, Zhejiang Province 317016, PR China.
Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, PR China.
Bioorg Chem. 2019 Apr;85:325-336. doi: 10.1016/j.bioorg.2019.01.019. Epub 2019 Jan 10.
In the scientific field, nanotechnology has offered multipurpose and designated functional nanoparticles (NPs) for the development of applications in nano-medicine. This present review focuses on cutting edge of nanotechnology in biomedical applications as drug carries in cancer treatment. The nanotechnology overcomes several limitations of drug delivery systems used in distinct therapeutic approaches of cancer treatment. The serious effect of conventional chemotherapeutics by nonspecific targeting, the lack of solubility, and the inability of chemotherapeutics entry to cancer cells which, offers a great opportunity for nanotechnology to play significant roles in cancer biology. The selective delivery of nano-drugs to the targeted cancer cells by the programmed way and avoiding nonspecific interactions to the healthy cells. The present review focuses on the methods of improving the size, shape and characteristics of nanomaterials which can be exploited for cancer therapy. The successful designing of nanocarriers can be tailored for cancer treatment for upcoming future as nano-medicines.
在科学领域,纳米技术为纳米医学应用的发展提供了多功能和指定功能的纳米颗粒(NPs)。本综述重点介绍了纳米技术在癌症治疗药物载体等生物医学应用方面的最新进展。纳米技术克服了癌症治疗不同治疗方法中使用的药物传递系统的几个局限性。传统化疗药物的非特异性靶向、缺乏溶解性以及化疗药物无法进入癌细胞等严重影响,为纳米技术在癌症生物学中发挥重要作用提供了巨大机会。纳米药物通过编程方式选择性递送到靶向癌细胞,避免与健康细胞发生非特异性相互作用。本综述重点介绍了改善纳米材料的大小、形状和特性的方法,这些方法可用于癌症治疗。纳米载体的成功设计可以针对未来的癌症治疗进行定制,作为纳米药物。