Department of Oral and Maxillofacial Surgery, Hunan Provincial People's Hospital and The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, People's Republic of China.
Hanwoo DNA Solutions Co., Ltd, Changsha, China.
Biol Trace Elem Res. 2019 Oct;191(2):348-353. doi: 10.1007/s12011-019-1639-4. Epub 2019 Jan 19.
Cadmium (Cd) is a widespread trace toxic heavy metal with long biological half-life and may induce higher risk of cancer on multiple organs of human body. Recent studies have confirmed that dental calculus has enormous potential for investigation of exposure to Cd in the human mouth by acting as a time capsule. We aimed to examine relationship between Cd levels in dental calculus due to betel-quid chewing and risk of oral cancer. This study included 85 male oral squamous cell carcinoma (SCC) cases with betel-quid chewing and smoking as observation subjects (group A) and 67 healthy people with smoking but without betel-quid chewing as control subjects (group B) in Hunan province of Mainland China. Cd levels in calcified dental calculus samples from all participants were measured by inductively coupled plasma mass spectrometry (ICP-MS). The results of this study indicated that cadmium levels in dental calculus were significantly higher in male oral SCC patients with betel-quid chewing and smoking than that in healthy individuals without habit of betel-quid chewing and with smoking (p < 0.0001). This study gives some evidence to support that there may be a positive relationship between cadmium in dental calculus due to betel-quid chewing and risk of oral SCC.
镉（Cd）是一种广泛存在的痕量有毒重金属，具有较长的生物半衰期，可能会增加人体多个器官患癌的风险。最近的研究证实，牙垢作为时间胶囊，对于研究人体口腔中镉的暴露具有巨大的潜力。我们旨在研究因咀嚼槟榔和吸烟而导致的牙垢中镉水平与口腔癌风险之间的关系。这项研究包括中国大陆湖南省的 85 名男性口腔鳞状细胞癌（SCC）病例，他们有咀嚼槟榔和吸烟的习惯（观察组 A），以及 67 名健康人，他们有吸烟习惯但没有咀嚼槟榔的习惯（对照组 B）。所有参与者的钙化牙垢样本中的镉水平均通过电感耦合等离子体质谱法（ICP-MS）进行测量。本研究结果表明，咀嚼槟榔和吸烟的男性口腔 SCC 患者的牙垢中镉水平明显高于没有咀嚼槟榔和吸烟习惯的健康人（p<0.0001）。本研究提供了一些证据，支持因咀嚼槟榔而导致的牙垢中的镉与口腔 SCC 风险之间可能存在正相关关系。
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