Department of Otorhinolaryngology, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal.
Department of Pathology, Faculty of Medicine of the University of Porto, Porto, Portugal.
Dermatol Ther. 2019 Mar;32(2):e12828. doi: 10.1111/dth.12828. Epub 2019 Jan 30.
Basal cell carcinoma is the most frequent malignant neoplasm in white-skinned individuals. It develops in different body areas, including in the scalp, which is a unique anatomical region due to the high number of pilosebaceous follicles; the scalp is protected from UV exposure, a main risk factor for basal cell carcinoma development. Moreover, scalp basal cell carcinoma has been described as more aggressive and difficult to treat than other forms of basal cell carcinoma. In this study, we reviewed the clinical and pathological characteristics, risk factors, genetics, and treatment options for scalp basal cell carcinoma to better understand this special type of cancer. Even though it is not yet clear whether scalp basal cell carcinomas represent a different entity, it seems important to give them special attention due to their potential aggressiveness, invasion capacities, tendency to relapse, and treatment difficulties.
基底细胞癌是白种人最常见的恶性肿瘤。它发生在不同的身体部位，包括头皮，由于毛发皮脂腺滤泡数量众多，头皮是一个独特的解剖区域；头皮受到紫外线照射的保护，这是基底细胞癌发展的主要危险因素。此外，头皮基底细胞癌已被描述为比其他形式的基底细胞癌更具侵袭性和更难治疗。在本研究中，我们回顾了头皮基底细胞癌的临床和病理特征、危险因素、遗传学和治疗选择，以更好地了解这种特殊类型的癌症。尽管目前尚不清楚头皮基底细胞癌是否代表一种不同的实体，但由于其潜在的侵袭性、复发倾向和治疗困难，似乎有必要对其给予特别关注。
