Department of Dermatology, The Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Laboratory for Regeneration Medicine, Jiangsu University, Zhenjiang, China.
Dermatol Ther. 2019 Mar;32(2):e12834. doi: 10.1111/dth.12834. Epub 2019 Feb 27.
Cutaneous CD30 lymphoproliferative disorders represent a spectrum of skin lymphatic reticular proliferative diseases, including lymphomatoid papulosis (LYP), primary cutaneous anaplastic large cell lymphoma (PC-ALCL), and borderline lesions between them. Although they all express CD30 as a phenotypic marker and share overlapping immunophenotypic features, they differ in clinical manifestations, pathological features, treatment, and prognosis. LYP is a kind of benign disease characterized by recurrent papules and nodules, and may spontaneously regress. PC-ALCL presents with solitary tumor or local grouped nodules characterized by large T-cells and may completely or partially resolve in fewer than half of cases. We reported a case of patient with clinical manifestation and pathologic features consistent with LYP in its early stages, which later turned into PC-ALCL. This patient was treated with acitretin combined with NB-UVB and had an obvious response.
皮肤 CD30 淋巴增生性疾病代表了一系列皮肤淋巴网状增殖性疾病，包括蕈样肉芽肿（LYP）、原发性皮肤间变性大细胞淋巴瘤（PC-ALCL）以及它们之间的交界性病变。尽管它们都表达 CD30 作为表型标志物，并具有重叠的免疫表型特征，但在临床表现、病理特征、治疗和预后方面存在差异。LYP 是一种良性疾病，表现为反复发作的丘疹和结节，并可能自发消退。PC-ALCL 表现为单发肿瘤或局部成簇结节，特征为大 T 细胞，不到一半的病例可完全或部分缓解。我们报告了一例患者，其临床表现和病理特征符合早期 LYP，后来发展为 PC-ALCL。该患者接受了阿维 A 联合 NB-UVB 治疗，反应明显。
