School of Pharmacy, University of Waterloo, 10A Victoria St S, Kitchener N2G 1C5, Canada.
School of Pharmacy, University of Waterloo, 10A Victoria St S, Kitchener N2G 1C5, Canada.
Adv Drug Deliv Rev. 2019 May;145:4-17. doi: 10.1016/j.addr.2019.01.003. Epub 2019 Jan 17.
The human body is a large reservoir for bacterial viruses known as bacteriophages (phages), which participate in dynamic interactions with their bacterial and human hosts that ultimately affect human health. The current growing interest in human resident phages is paralleled by new uses of phages, including the design of engineered phages for therapeutic applications. Despite the increasing number of clinical trials being conducted, the understanding of the interaction of phages and mammalian cells and tissues is still largely unknown. The presence of phages in compartments within the body previously considered purely sterile, suggests that phages possess a unique capability of bypassing anatomical and physiological barriers characterized by varying degrees of selectivity and permeability. This review will discuss the direct evidence of the accumulation of bacteriophages in various tissues, focusing on the unique capability of phages to traverse relatively impermeable barriers in mammals and its relevance to its current applications in therapy.
人体是一种大型的细菌病毒储存库，这些病毒被称为噬菌体（phages），它们与细菌和人类宿主进行着动态的相互作用，最终影响人类健康。目前，人们对人体常驻噬菌体越来越感兴趣，同时也出现了噬菌体的新用途，包括设计用于治疗应用的工程噬菌体。尽管正在进行越来越多的临床试验，但人们对噬菌体与哺乳动物细胞和组织相互作用的理解仍知之甚少。噬菌体存在于以前被认为是纯粹无菌的身体部位，这表明噬菌体具有独特的能力，可以绕过具有不同选择性和渗透性的解剖学和生理学屏障。本文将讨论噬菌体在各种组织中积累的直接证据，重点讨论噬菌体在哺乳动物中穿越相对不可渗透屏障的独特能力及其与目前治疗应用的相关性。
