先天性颅后窝未成熟畸胎瘤可伴 20 年生存结局：病例报告及文献复习。
Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature.
机构信息
Division of Neurological Surgery, Department of Surgery, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.
Department of Pathology, King Abdulaziz University Hospital, P.O. Box 9946, Jeddah, 21423, Kingdom of Saudi Arabia.
出版信息
World J Surg Oncol. 2019 Jan 19;17(1):22. doi: 10.1186/s12957-019-1564-1.
BACKGROUND
Congenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis.
CASE PRESENTATION
A newborn female, diagnosed prenatally with hydrocephalus, is presented at birth with increasing head circumference and Parinaud's syndrome. Magnetic resonance imaging scans demonstrated a huge posterior fossa tumor with obstructive hydrocephalus. At surgery, through a suboccipital craniotomy, complete excision was achieved of a histological-proven immature teratoma. The infant received adjuvant chemotherapy for 1 year. She had normal neurological development and remained tumor-free through her 20-year follow-up.
CONCLUSION
The authors report this rare case of congenital posterior fossa teratoma with long-term outcome, and the literature is reviewed.
背景
先天性颅内肿瘤非常罕见，占儿童脑肿瘤的比例不到 2%。畸胎瘤约占三分之一至一半，主要位于幕上中线部位。后颅窝部位罕见，根据文献报道，预后通常较差。
病例介绍
一名新生女性，产前诊断为脑积水，出生时出现头围增大和 Parinaud 综合征。磁共振成像扫描显示巨大的后颅窝肿瘤合并梗阻性脑积水。手术中，通过枕下入路开颅术，完整切除了经组织学证实的未成熟畸胎瘤。患儿接受了 1 年的辅助化疗。在 20 年的随访中，她神经发育正常，无肿瘤复发。
结论
作者报告了这例罕见的先天性后颅窝畸胎瘤病例，并对文献进行了回顾。
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