载磁聚乙二醇化树枝状大分子接枝温敏聚合物用于来曲唑药物递送的合成与表征。
Synthesis and characterization of magnetized-PEGylated dendrimer anchored to thermosensitive polymer for letrozole drug delivery.
机构信息
Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran.
Department of Chemistry, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
出版信息
Colloids Surf B Biointerfaces. 2019 Apr 1;176:404-411. doi: 10.1016/j.colsurfb.2019.01.014. Epub 2019 Jan 11.
Letrozole as a target loaded drug on siliceous magnetized FeO nanoparticles grafted with high-branched dendrimers. Grafted polymer coating contained N-vinyl caprolactam as a stimulus-responsive polymer which functionalized with five generations of dendrimers containing oxime functional group. The precursors underwent PEGylating polymerization to form PEGylated dendrimer coating on the particle surface as the final carrier. The final product has the average size of ˜79 nm. The final product characterized by FT-IR, TGA, VSM, SEM-EDAX to investigate carrier features further. Some characteristic parameters in adsorption process like pH, time, the temperature investigated for letrozole using the final carrier. The physical and chemical properties of the final polymerized generations were also studied. Letrozole releasing process examined in the simulated intestinal fluid (pH = 7.4) revealed 95% of letrozole released during 25 h which also considered by Korsmeyer-Peppas equation to verify Fickian diffusion mechanism.
载有来曲唑的硅基磁性 FeO 纳米颗粒接枝高支化树枝状聚合物。接枝聚合物涂层含有 N-乙烯基己内酰胺作为刺激响应聚合物，其功能化有包含肟官能团的五代树枝状聚合物。前体经历 PEGylating 聚合，在颗粒表面形成 PEG 化树枝状聚合物涂层作为最终载体。最终产物的平均粒径约为 79nm。通过傅里叶变换红外光谱（FT-IR）、热重分析（TGA）、振动样品磁强计（VSM）、扫描电子显微镜-能谱分析（SEM-EDAX）等对载体特征进行进一步研究。使用最终载体研究了来曲唑吸附过程中的一些特征参数，如 pH 值、时间和温度。还研究了最终聚合代的物理化学性质。在模拟肠液（pH=7.4）中进行的来曲唑释放过程表明，在 25 小时内释放了 95%的来曲唑，这也通过 Korsmeyer-Peppas 方程来验证了 Fickian 扩散机制。
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