"Alexandru Ioan Cuza" University of Iasi, Department of Research, Faculty of Biology, Bd. Carol I, 20 A, 700505 Iasi, Romania.
"Alexandru Ioan Cuza" University of Iasi, Department of Biology, Faculty of Biology, Bd. Carol I, 20 A, 700505 Iasi, Romania.
Ecotoxicol Environ Saf. 2019 Apr 30;171:854-862. doi: 10.1016/j.ecoenv.2019.01.057. Epub 2019 Jan 18.
In this study zebrafish specimens were exposed for 15 days to 0.25, 0.5, 1 and 2 μg L non-lethal concentrations of deltamethrin (DM) knowing that is the active compound in insecticides used on agricultural crops. They were investigated important issues resulted during the chronic exposure with DM: effects on aggressive behavior and swimming performances knowing that is a high neurotoxic compound; toxicity on nervous system investigated on telencephalon, optic tectum and cerebellum; activity of PCNA, p53 and TUNEL as toxicity markers in immunocytochemistry of the histological samples; changes of elements concentrations in the fish body and their role in detoxification of DM. This scenario investigated the harmful effects of this compound for freshwater fish communities. The aggressive behavior significantly increased and remained constant for the concentration 0.5 μg L. They were not evidences in changing of anxiety level and swimming performances. The nervous system suffered significant damage for all studied concentrations and confirmed the changes in the behavior. Selenium concentration in the body decreased and may be involved in the detoxification processes.
在这项研究中，斑马鱼标本在非致死浓度的 0.25、0.5、1 和 2μg/L 溴氰菊酯（DM）中暴露 15 天，因为 DM 是农业作物中使用的杀虫剂的活性化合物。研究了 DM 慢性暴露期间产生的重要问题：对攻击性行为和游泳表现的影响，因为 DM 是一种高神经毒性化合物；对端脑、视顶盖和小脑的神经系统毒性；PCNA、p53 和 TUNEL 的活性作为组织学样本免疫细胞化学中的毒性标志物；鱼体内元素浓度的变化及其在 DM 解毒中的作用。这种情况研究了这种化合物对淡水鱼类群落的有害影响。在 0.5μg/L 的浓度下，攻击性行为显著增加并保持不变。焦虑水平和游泳表现没有变化的证据。神经系统在所有研究浓度下都受到了显著的损害，这证实了行为的变化。体内硒浓度降低，可能参与了解毒过程。
