Sher B T, Bargatze R, Holzmann B, Gallatin W M, Matthews D, Wu N, Picker L, Butcher E C, Weissman I L
Department of Pathology, Stanford University School of Medicine, California 94305.
Adv Cancer Res. 1988;51:361-90. doi: 10.1016/s0065-230x(08)60226-2.
As discussed in the preceding sections, there are several indications that the lymphocyte homing receptors involved in the normal process of lymphocyte recirculation are also relevant to the behavior of metastatic cells. Cell fusion experiments indicate that previously nonmetastatic cells can acquire metastatic capacity from fusion with normal lymphocytes. Murine T lymphomas that bear high levels of functional homing receptors can metastasize to peripheral lymphoid organs, whereas those lymphomas lacking homing receptors cannot. Virtually all lymph node metastases of lymphomas contain a high proportion of MEL-14hi cells, even if the primary tumor has been selected to be relatively deficient in these cells. Further investigations of the biology of lymphocyte homing receptors will reveal whether or not there are additional lymphocyte homing receptors and will clarify the role of lymphocyte homing receptors in metastasis. Antibodies against three lymphocyte homing receptors could therefore be useful for diagnosis and treatment of metastatic disease.
如前所述，有几个迹象表明，参与淋巴细胞再循环正常过程的淋巴细胞归巢受体也与转移细胞的行为有关。细胞融合实验表明，以前无转移能力的细胞可通过与正常淋巴细胞融合而获得转移能力。携带高水平功能性归巢受体的小鼠T淋巴瘤可转移至外周淋巴器官，而那些缺乏归巢受体的淋巴瘤则不能。实际上，淋巴瘤的所有淋巴结转移灶都含有高比例的MEL-14hi细胞，即使原发肿瘤已被选择为这些细胞相对缺乏。对淋巴细胞归巢受体生物学的进一步研究将揭示是否存在其他淋巴细胞归巢受体，并将阐明淋巴细胞归巢受体在转移中的作用。因此，针对三种淋巴细胞归巢受体的抗体可能对转移性疾病的诊断和治疗有用。
