基于负载钌掺杂 TiO2 纳米粒子的多壁碳纳米管的传感器，用于检测氟芬那酸和甲芬那酸。
Sensors based on ruthenium-doped TiO nanoparticles loaded into multi-walled carbon nanotubes for the detection of flufenamic acid and mefenamic acid.
机构信息
Electrochemistry and Materials Group, Department of Chemistry, K. L. E. Institute of Technology, Gokul, Hubballi, 580 030, India; Visvesvaraya Technological University, Karnataka, India; Department of Chemistry and Biochemistry, Lamar University, Beaumont, TX, 77710, USA.
Electrochemistry and Materials Group, Department of Chemistry, K. L. E. Institute of Technology, Gokul, Hubballi, 580 030, India; Visvesvaraya Technological University, Karnataka, India.
出版信息
Anal Chim Acta. 2019 Mar 21;1051:58-72. doi: 10.1016/j.aca.2018.11.041. Epub 2018 Nov 24.
Recent advances to utilize two or more nanoparticles for developing novel sensors with superior sensitivity have spurred advanced detection limits even at low concentrations. In this research, a blend of rutheniumdoped TiO (Ru-TiO) nanoparticles and multiwalled carbon nanotubes (MWCNTs) loaded into carbon paste matrix to fabricate a novel Ru-TiO/MWCNTs-CPE sensor was used for the detection and quantification of flufenamic acid (FFA) and mefenamic acid (MFA) drugs. The surface morphology of Ru-TiO was assessed by scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), transmission electron microscopy (TEM), X-ray diffraction (XRD) and atomic force microscopy (AFM). Sensitivity and selectivity of the electrode was improved at the Ru-TiO/MWCNTs modified CPE compared to nascent CPE due to the amazing surface distinctive characteristics of the modifier at pH 5.0. The effect of concentration of the modifier, pH, pre-concentration time, sweep rate and concentration on signal enhancement of FFA and MFA was studied. The square wave voltammetry (SWV) currents are linearly related in the concentration range of 0.01 μM-0.9 μM with the detection limit values of 0.68 nM for FFA and 0.45 nM for MFA, respectively. The developed electrode assembly was used for the quantification of both the drug analytes in human urine samples.
最近，利用两种或多种纳米粒子开发具有更高灵敏度的新型传感器的进展，甚至在低浓度下也能刺激先进的检测极限。在这项研究中，将掺钌的二氧化钛（Ru-TiO）纳米粒子和多壁碳纳米管（MWCNTs）混合装入碳糊基质中，用于制备新型 Ru-TiO/MWCNTs-CPE 传感器，用于检测和定量氟芬酸（FFA）和甲芬那酸（MFA）药物。Ru-TiO 的表面形貌通过扫描电子显微镜（SEM）、能量色散 X 射线光谱（EDX）、透射电子显微镜（TEM）、X 射线衍射（XRD）和原子力显微镜（AFM）进行评估。与原始 CPE 相比，由于修饰剂在 pH 5.0 时具有惊人的表面独特特性，因此 Ru-TiO/MWCNTs 修饰的 CPE 提高了电极的灵敏度和选择性。研究了修饰剂浓度、pH 值、预浓缩时间、扫描速率和浓度对 FFA 和 MFA 信号增强的影响。方波伏安法（SWV）电流在 0.01 μM-0.9 μM 的浓度范围内呈线性关系，FFA 的检测限值为 0.68 nM，MFA 的检测限值为 0.45 nM。所开发的电极组件用于定量分析人尿液样品中的两种药物分析物。
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