Pezeshki Najafabadi Maryam, Dagoohian Afsaneh, Rajaie Soheila, Zarkesh-Esfahani Sayyed Hamid, Edalati Masoud
a Mahdieh Medical Diagnostic Center Charity.
b Department of Biology, Faculty of Sciences , University of Isfahan , Isfahan , Iran.
J Chemother. 2018 Oct-Dec;30(6-8):348-353. doi: 10.1080/1120009X.2018.1525120.
Urinary tract infections (UTIs) are considered the most common community-acquired infections worldwide, which have possible complications along with significant economic impact on national healthcare systems. The aim of this study was to identify the most common causes of significant bacteriuria and to assess their antimicrobial resistance pattern in the Isfahan province of Iran. In this cross-sectional study, 11,678 urine samples of the patients referred to Mahdieh Medical Diagnostic Centre Charity were examined over a period of 10 months (from September 2015 to June 2016). Among the cases, 6.85% were positive for bacteriuria (F/M = 11.3). Escherichia coli (62%) was the most frequently isolated bacteria, followed by Staphylococcus epidermidis (13.9%) and Staphylococcus aureus (6.8%). E. coli was more prevalent among patients with diabetes mellitus. E. coli isolates showed the highest resistance to nalidixic acid, Trimethoprim/Sulfamethoxazole and Cefixime. Our results revealed that broad-spectrum antibiotic resistance is frequent among isolated uropathogens in Isfahan, Iran.
尿路感染（UTIs）被认为是全球最常见的社区获得性感染，可能引发并发症，并对国家医疗系统造成重大经济影响。本研究的目的是确定导致显著菌尿的最常见原因，并评估伊朗伊斯法罕省这些病因的抗菌药物耐药模式。在这项横断面研究中，对转诊至马赫迪耶医疗诊断中心慈善机构的患者的11678份尿液样本进行了为期10个月（从2015年9月至2016年6月）的检查。在这些病例中，6.85%的患者菌尿呈阳性（男/女 = 11.3）。大肠埃希菌（62%）是最常分离出的细菌，其次是表皮葡萄球菌（13.9%）和金黄色葡萄球菌（6.8%）。大肠埃希菌在糖尿病患者中更为普遍。大肠埃希菌分离株对萘啶酸、甲氧苄啶/磺胺甲恶唑和头孢克肟的耐药性最高。我们的研究结果显示，在伊朗伊斯法罕分离出的尿路病原体中，广谱抗生素耐药现象很常见。
