School of Kinesiology, Shanghai University of Sport, 188 Hengren Road, Shanghai 200438, China.
School of Kinesiology, Shanghai University of Sport, 188 Hengren Road, Shanghai 200438, China.
Steroids. 2019 Mar;143:91-96. doi: 10.1016/j.steroids.2019.01.003. Epub 2019 Jan 18.
Age-related muscle wasting (sarcopenia) is accompanied by a decrease in estrogen levels which can compromise the health of aging women. Recent studies have shown that the key enzyme of estrogen synthesis (aromatase) is detected in the skeletal muscle. The purpose of this study was to investigate the effects of exercise on the expression of aromatase and the synthesis of sex steroid hormones in skeletal muscle following exercise training. Ovariectomized rats were divided into two groups, treadmill running group (25 m/min, 60 min/day, 6 days/week) and sedentary group. We found that in ovariectomized rats, exercise training significantly increased the soleus and plantar muscles mass. The level of aromatase expression and 17-β-estradiol (E2) were increased significantly in skeletal muscle following exercise training. In addition, activation of the down-stream Akt-FoxO1-MyoD signaling pathway was significantly increased in both soleus and plantaris muscles following exercise. These results demonstrate that exercise training increased the expression of aromatase and local estrogen production in skeletal muscle, which potentially influences skeletal muscle in ovariectomized rats through activation of the Akt-FoxO1-MyoD signaling pathway.
与年龄相关的肌肉减少症（肌少症）伴随着雌激素水平的下降，这可能会影响老年女性的健康。最近的研究表明，雌激素合成的关键酶（芳香酶）在骨骼肌中被检测到。本研究旨在探讨运动对去卵巢大鼠运动训练后骨骼肌中芳香酶表达和性激素合成的影响。去卵巢大鼠分为两组，即跑步机跑步组（25m/min，60min/天，6 天/周）和安静组。我们发现，在去卵巢大鼠中，运动训练显著增加了比目鱼肌和跖肌的质量。运动训练后，骨骼肌中芳香酶的表达和 17-β-雌二醇（E2）水平显著增加。此外，运动后比目鱼肌和跖肌中下游 Akt-FoxO1-MyoD 信号通路的激活显著增加。这些结果表明，运动训练增加了骨骼肌中芳香酶的表达和局部雌激素的产生，这可能通过激活 Akt-FoxO1-MyoD 信号通路影响去卵巢大鼠的骨骼肌。
