运动在雌激素缺乏诱导的肌肉减少症中的作用。
Role of exercise in estrogen deficiency-induced sarcopenia.
作者信息
Cho Eun-Jeong, Choi Youngju, Jung Su-Jeen, Kwak Hyo-Bum
机构信息
Department of Biomedical Science, Program in Biomedical Science and Engineering, Inha University, Incheon, Korea.
Institute of Sports & Arts Convergence, Inha University, Incheon, Korea.
出版信息
J Exerc Rehabil. 2022 Feb 24;18(1):2-9. doi: 10.12965/jer.2244004.002. eCollection 2022 Feb.
Abstract
A decline in estrogen levels during menopause is associated with the loss of muscle mass and function, and it can accelerate sarcopenia. However, with the growing number of postmenopausal women due to the increase in life expectancy, the effects of estrogen on skeletal muscle are not completely understood. This article reviews the relationship between estrogen deficiency and skeletal muscle, its potential mechanisms, including those involving mitochondria, and the effects of exercise on estrogen deficiency-induced skeletal muscle impairment. In particular, mitochondrial dysfunction induced by estrogen deficiency accelerates sarcopenia via mitochondrial dynamics, mitophagy, and mitochondrial-mediated apoptosis. It is well known that exercise training is essential for health, including for the improvement of sarcopenia. This review highlights the importance of exercise training (aerobic and resistance exercise) as a therapeutic intervention against estrogen deficiency-induced sarcopenia.
摘要
更年期雌激素水平下降与肌肉质量和功能的丧失有关，并且会加速肌肉减少症。然而，随着预期寿命的增加，绝经后女性数量不断增多，雌激素对骨骼肌的影响尚未完全明确。本文综述了雌激素缺乏与骨骼肌之间的关系、其潜在机制（包括涉及线粒体的机制）以及运动对雌激素缺乏所致骨骼肌损伤的影响。特别是，雌激素缺乏引起的线粒体功能障碍通过线粒体动力学、线粒体自噬和线粒体介导的细胞凋亡加速了肌肉减少症。众所周知，运动训练对健康至关重要，包括对改善肌肉减少症。本综述强调了运动训练（有氧运动和抗阻运动）作为针对雌激素缺乏所致肌肉减少症的治疗干预措施的重要性。
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