Katz Ben Z, Collin Simon M, Murphy Gabrielle, Moss-Morris Rona, Wyller Vegard Bruun, Wensaas Knut-Arne, Hautvast Jeannine L A, Bleeker-Rovers Chantal P, Vollmer-Conna Ute, Buchwald Dedra, Taylor Renée, Little Paul, Crawley Esther, White Peter D, Lloyd Andrew
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, USA.
Centre for Child & Adolescent Health, School of Social & Community Medicine, University of Bristol, UK.
Fatigue. 2018;6(2):106-121. doi: 10.1080/21641846.2018.1426086. Epub 2018 Jan 19.
The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.
COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. The 9 cohorts closed to recruitment total over 3,000 participants, including nearly 1000 with infectious mononucleosis (IM), > 500 with Q fever, > 800 with giardiasis, > 600 with campylobacter gastroenteritis (CG), 190 with Legionnaires disease and 60 with Ross River virus. Follow-ups have been at least 6 months and up to 10 years. All studies use the Fukuda criteria for defining chronic fatigue syndrome (CFS).
Preliminary analyses indicated that risk factors for non-recovery from PIF included lower physical fitness, female gender, severity of the acute sickness response, and autonomic dysfunction.
COFFI (https://internationalcoffi.wordpress.com/) is an international collaboration which should be able to answer questions based on pooled data that are not answerable in the individual cohorts. Possible questions may include the following: Do different infectious triggers different PIF syndromes (e.g., CFS vs. irritable bowel syndrome)?; What are longitudinal predictors of PIF and its severity?
感染后疲劳协作组（COFFI）的目的是让感染后疲劳（PIF）及其他综合征的研究人员通过研究具有已知感染诱因的相对同质人群，就这些神秘且了解不足的病症展开合作。利用COFFI，汇总数据和存储的生物样本将支持流行病学和实验室研究，以更好地了解PIF发生发展及进展的病因和风险因素。
COFFI由来自英国、荷兰、挪威、美国、新西兰和澳大利亚的前瞻性队列组成，部分队列已结束招募，部分队列仍在招募。9个已结束招募的队列共有3000多名参与者，其中包括近1000例传染性单核细胞增多症（IM）患者、500多例Q热患者、800多例贾第虫病患者、600多例弯曲杆菌性肠胃炎（CG）患者、190例军团病患者和60例罗斯河病毒患者。随访时间至少为6个月，最长达10年。所有研究均使用福田标准来定义慢性疲劳综合征（CFS）。
初步分析表明，PIF未恢复的风险因素包括身体素质较差、女性、急性疾病反应的严重程度和自主神经功能障碍。
