Department of Experimental, Diagnostic and Specialty Medicine, Division of Dermatology, University of Bologna , Bologna , Italy.
J Dermatolog Treat. 2019 Dec;30(8):757-759. doi: 10.1080/09546634.2019.1573308. Epub 2019 Feb 6.
Treatment of alopecia areata (AA) involves use of high potency topical corticosteroids under occlusion that, even very effective, can lead to several adverse effects. We report 10 cases of patients with AA that, after using high potency topical corticosteroids, have developed tinea versicolor of the neck area. Ten patients with AA, aged 18-38 years, were prescribed with clobetasone propionate 0.05% cream under occlusion every other day but, after 3-4 months of treatment, they returned to our facility complaining the appearance of multiple white or red-brown round or oval macules in the neck area. Diagnosis of pityriasis versicolor was confirmed by direct microscopy examination of skin scrapings in 10% potassion hydroxide (KOH) solution. All patients received systemic antifungal therapy associated with the daily use of ketoconazole shampoo. Tinea versicolor of the neck should be included among a rare but possible side effect of prolonged application of high potency topical steroids on the scalp. These cases reinforce the importance of careful dermatologic examination and recommend preventive measures in patients with alopecia areata that are using these drugs.
斑秃(AA)的治疗包括在封闭条件下使用强效外用皮质类固醇,尽管非常有效,但可能会导致多种不良反应。我们报告了 10 例 AA 患者,他们在使用强效外用皮质类固醇后,颈部出现花斑癣。10 例 AA 患者年龄在 18-38 岁之间,隔日给予丙酸氯倍他索 0.05%乳膏外用,但在治疗 3-4 个月后,他们回到我们的机构,抱怨颈部出现多个白色或红棕色的圆形或椭圆形斑疹。在 10%氢氧化钾(KOH)溶液中直接镜检皮肤刮屑,确诊为花斑癣。所有患者均接受系统性抗真菌治疗,并联合酮康唑洗发水每日使用。颈部花斑癣应包括在头皮长期使用强效外用类固醇的罕见但可能的副作用之一。这些病例强调了在使用这些药物的斑秃患者中进行仔细皮肤科检查和建议预防措施的重要性。