Laboratory of Exercise Physiology-Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro De Bosis 6, 00135 Roma, Italy.
Laboratory of Biochemistry of Movement-Department of Movement, Human and Health Sciences, Università degli Studi di Roma "Foro Italico", Piazza Lauro De Bosis 6, 00135 Roma, Italy.
Nutrients. 2019 Jan 21;11(1):205. doi: 10.3390/nu11010205.
The aim of the present investigation was to test the hypothesis that quercetin (Q) may prevent the strength loss and neuromuscular impairment associated with eccentric exercise-induced muscle damage (EEIMD). Twelve young men (26.1 ± 3.1 years) ingested either Q (1000 mg/day) or placebo (PLA) for 14 days using a randomized, double-blind, crossover study design. Participants completed a comprehensive neuromuscular (NM) evaluation before, during and after an eccentric protocol able to induce a severe muscle damage (10 sets of 10 maximal lengthening contractions). The NM evaluation comprised maximal voluntary isometric contraction (MVIC) and force⁻velocity relationship assessments with simultaneous recording of electromyographic signals (EMG) from the elbow flexor muscles. Soreness, resting arm angle, arm circumference, plasma creatine kinase (CK) and lactate dehydrogenase (LDH) were also assessed. Q supplementation significantly increased the isometric strength recorded during MVIC compared to baseline (+4.7%, < 0.05). Moreover, the torque and muscle fiber conduction velocity (MFCV) decay recorded during the eccentric exercise was significant lower in Q compared to PLA. Immediately after the EEIMD, isometric strength, the force⁻velocity relationship and MFCV were significantly lower when participants were given PLA rather than Q. Fourteen days of Q supplementation seems able to attenuate the severity of muscle weakness caused by eccentric-induced myofibrillar disruption and sarcolemmal action potential propagation impairment.
本研究旨在验证槲皮素（Q）可能预防离心运动引起的肌肉损伤（EEIMD）导致的力量下降和神经肌肉功能障碍的假设。12 名年轻男性（26.1±3.1 岁）采用随机、双盲、交叉研究设计，连续 14 天每天摄入 Q（1000mg/天）或安慰剂（PLA）。参与者在进行能够引起严重肌肉损伤的离心方案之前、期间和之后完成了全面的神经肌肉（NM）评估（10 组 10 次最大延长收缩）。NM 评估包括最大等长收缩（MVIC）和力-速度关系评估，并同时记录肘部屈肌的肌电图（EMG）信号。还评估了酸痛、休息时手臂角度、手臂周长、血浆肌酸激酶（CK）和乳酸脱氢酶（LDH）。与基线相比，Q 补充剂可显著增加 MVIC 记录的等长力量（+4.7%，<0.05）。此外，与 PLA 相比，在 Q 中记录的离心运动期间的扭矩和肌纤维传导速度（MFCV）衰减明显更低。在 EEIMD 后，当参与者给予 PLA 而不是 Q 时，等长力量、力-速度关系和 MFCV 明显降低。14 天的 Q 补充似乎能够减轻由离心引起的肌原纤维破坏和肌细胞膜动作电位传播障碍引起的肌肉无力的严重程度。
