食用生姜对2型糖尿病患者血糖状态、血脂水平及一些炎症标志物的影响。
The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.
作者信息
Arablou Tahereh, Aryaeian Naheed, Valizadeh Majid, Sharifi Faranak, Hosseini AghaFatemeh, Djalali Mahmoud
机构信息
Department of Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences , Tehran , Iran .
出版信息
Int J Food Sci Nutr. 2014 Jun;65(4):515-20. doi: 10.3109/09637486.2014.880671. Epub 2014 Feb 4.
OBJECTIVE
To assess the effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus.
METHODS
In a double-blinded, placebo-controlled clinical trial, 70 type 2 diabetic patients were enrolled. They allocated randomly into ginger group and control group. They consumed 1600 mg ginger versus 1600 mg wheat flour placebo daily for 12 weeks. Serum sugar, lipids, CRP, PGE2 and TNFα were measured before and after intervention.
RESULTS
Ginger reduced fasting plasma glucose, HbA1C, insulin, HOMA, triglyceride, total cholesterol, CRP and PGE₂ significantly compared with placebo group (p < 0.05). There were no significant differences in HDL, LDL and TNFα between two groups (p > 0.05).
CONCLUSION
Ginger improved insulin sensitivity and some fractions of lipid profile, and reduced CRP and PGE₂ in type 2 diabetic patients. Therefore ginger can be considered as an effective treatment for prevention of diabetes complications.
目的
评估食用生姜对2型糖尿病患者血糖状态、血脂水平及一些炎症标志物的影响。
方法
在一项双盲、安慰剂对照的临床试验中，纳入了70例2型糖尿病患者。他们被随机分为生姜组和对照组。他们每天分别食用1600毫克生姜和1600毫克小麦粉安慰剂，持续12周。在干预前后测量血清糖、血脂、CRP、PGE2和TNFα。
结果
与安慰剂组相比，生姜显著降低了空腹血糖、糖化血红蛋白、胰岛素、稳态模型评估胰岛素抵抗指数、甘油三酯、总胆固醇、CRP和PGE₂（p < 0.05）。两组之间的高密度脂蛋白、低密度脂蛋白和TNFα无显著差异（p > 0.05）。
结论
生姜改善了2型糖尿病患者的胰岛素敏感性和部分血脂水平，并降低了CRP和PGE₂。因此，生姜可被视为预防糖尿病并发症的有效治疗方法。
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