Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA, USA.
Nat Rev Nephrol. 2019 Apr;15(4):196-197. doi: 10.1038/s41581-019-0114-y.
Scientists have long wondered how maternal diabetes, malnutrition and placental dysfunction impair fetal nephrogenesis. Anew study discovered a link between prenatal metabolic stress and nephron deficit via dysregulation of DNA methylation — an epigenetic mechanism that is essential for the renewal and differentiation of nephron progenitors.
长期以来，科学家们一直想知道母体糖尿病、营养不良和胎盘功能障碍是如何损害胎儿肾发生的。一项新的研究发现，产前代谢应激与肾单位缺陷之间存在联系，其通过 DNA 甲基化的失调来实现，而 DNA 甲基化是肾祖细胞更新和分化所必需的表观遗传机制。
